| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From INSERM U 360 (Drs. Elbaz, Alpérovitch, and Tzourio), Recherches Epidémiologiques en Neurologie et Psychopathologie, Hôpital de la Salpêtrière, Paris, France; Institute of Hygiene (Dr. Grigoletto), University of Padua, Padova, Italy; Targeted Project on Aging (Dr. Baldereschi), National Research Council, Florence, Italy; Department of Epidemiology and Biostatistics (Dr. Breteler), Erasmus University Medical School, Rotterdam, the Netherlands; Department of Neurology (Dr. Manubens-Bertran, University of Navarra, Pamplona, Spain; Department of Neurology (Dr. Lopez-Pousa), University Hospital Sta. Caterina, Girona, Spain; Department of Neurology (Dr. Dartigues), Pellegrin Hospital, University of Bordeaux II, France; and the Departments of Health Sciences Research and Neurology (Dr. Rocca), Mayo Clinic and Mayo Foundation, Rochester, MN.
Address correspondence and reprint requests to Dr A. Elbaz, INSERM U 360, Recherches Epidémiologiques en Neurologie et Psychopathologie, Hôpital de la Salpêtrière, 75651 Paris Cedex 13, France; e-mail: elbaz{at}ccr.jussieu.fr
OBJECTIVE: To investigate the familial aggregation of PD in a large collaborative population-based case-control study.
BACKGROUND: Most previous case-control studies of the familial aggregation of PD have been hospital- or clinic-based.
METHODS: We included 219 prevalent cases ascertained in three European populations (centers), using a two-phase design consisting of screening and examination by a neurologist. Each case was matched by age, sex, and center to three controls drawn from the same populations (n = 657). Presence of PD among first-degree relatives (parents and siblings) was determined using the family history approach for 175 cases and 481 controls.
RESULTS: Overall, a positive family history (at least one parent or sibling affected by PD) was reported in 10.3% of patients and 3.5% of controls (odds ratio [OR] = 3.2; 95% confidence interval [CI] = 1.6 to 6.6). A similar association was observed when analyses were restricted to nondemented patients and controls (OR = 3.9; 95% CI = 1.7 to 8.7) or to newly diagnosed patients (OR = 3.3; 95% CI = 0.9 to 11.9). We found a significant trend of increasing risk with increasing number of affected relatives (p = 0.003). Analyses stratified by age showed a stronger association for younger PD patients (OR = 7.6; 95% CI = 1.5 to 38.9) than for older patients (OR = 2.5; 95% CI = 1.1 to 5.7).
CONCLUSIONS: In this large sample of prevalent PD patients and population-matched controls, PD significantly aggregates in families, with the strength of the association being age-dependent. Therefore, familial factors, which can be genetic, environmental, or both, play a role in PD.
This article has been cited by other articles:
|
|
 |
|
  P. Ibanez, S. Lesage, S. Janin, E. Lohmann, F. Durif, A. Destee, A.-M. Bonnet, C. Brefel-Courbon, S. Heath, D. Zelenika, et al. {alpha}-Synuclein Gene Rearrangements in Dominantly Inherited Parkinsonism: Frequency, Phenotype, and Mechanisms Arch Neurol, January 1, 2009; 66(1): 102 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Mizuta, W. Satake, Y. Nakabayashi, C. Ito, S. Suzuki, Y. Momose, Y. Nagai, A. Oka, H. Inoko, J. Fukae, et al. Multiple candidate gene analysis identifies {alpha}-synuclein as a susceptibility gene for sporadic Parkinson's disease Hum. Mol. Genet., April 1, 2006; 15(7): 1151 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Josephs, J. Y. Matsumoto, and J. E. Ahlskog Benign tremulous parkinsonism. Arch Neurol, March 1, 2006; 63(3): 354 - 357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Berg, K. J. Schweitzer, P. Leitner, A. Zimprich, P. Lichtner, P. Belcredi, T. Brussel, C. Schulte, S. Maass, T. Nagele, et al. Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease* Brain, December 1, 2005; 128(12): 3000 - 3011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Frigerio, A. Elbaz, K. R. Sanft, B. J. Peterson, J. H. Bower, J. E. Ahlskog, B. R. Grossardt, M. de Andrade, D. M. Maraganore, and W. A. Rocca Education and occupations preceding Parkinson disease: A population-based case-control study Neurology, November 22, 2005; 65(10): 1575 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Atadzhanov, A Zumla, and P Mwaba Study of familial Parkinson's disease in Russia, Uzbekistan, and Zambia Postgrad. Med. J., February 1, 2005; 81(952): 117 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Spanaki and A. Plaitakis Bilineal transmission of Parkinson disease on Crete suggests a complex inheritance Neurology, March 9, 2004; 62(5): 815 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Levecque, A Elbaz, J Clavel, J S Vidal, P Amouyel, A Alperovitch, C Tzourio, and M C Chartier-Harlin Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease J. Neurol. Neurosurg. Psychiatry, March 1, 2004; 75(3): 478 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Karamohamed, A. L. DeStefano, J. B. Wilk, C. M. Shoemaker, L. I. Golbe, M. H. Mark, A. M. Lazzarini, O. Suchowersky, N. Labelle, M. Guttman, et al. A haplotype at the PARK3 locus influences onset age for Parkinson's disease: The GenePD study Neurology, December 9, 2003; 61(11): 1557 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Pankratz, W. C. Nichols, S. K. Uniacke, C. Halter, J. Murrell, A. Rudolph, C. W. Shults, P. M. Conneally, T. Foroud, and the Parkinson Study Group Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families Hum. Mol. Genet., October 16, 2003; 12(20): 2599 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Louis, G. Levy, H. Mejia-Santana, L. Cote, H. Andrews, J. Harris, C. Waters, B. Ford, S. Frucht, S. Fahn, et al. Risk of action tremor in relatives of tremor-dominant and postural instability gait disorder PD Neurology, October 14, 2003; 61(7): 931 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. J. Dekker, V. Bonifati, and C. M. van Duijn Parkinson's disease: piecing together a genetic jigsaw Brain, August 1, 2003; 126(8): 1722 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Elbaz, S.K. McDonnell, D.M. Maraganore, K.J. Strain, D.J. Schaid, J.H. Bower, J.E. Ahlskog, and W.A. Rocca Validity of family history data on PD: Evidence for a family information bias Neurology, July 8, 2003; 61(1): 11 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Periquet, M. Latouche, E. Lohmann, N. Rawal, G. De Michele, S. Ricard, H. Teive, V. Fraix, M. Vidailhet, D. Nicholl, et al. Parkin mutations are frequent in patients with isolated early-onset parkinsonism Brain, June 1, 2003; 126(6): 1271 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Foltynie, S Sawcer, C Brayne, and R A Barker The genetic basis of Parkinson's disease J. Neurol. Neurosurg. Psychiatry, October 1, 2002; 73(4): 363 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W C Nichols, N Pankratz, S K Uniacke, M W Pauciulo, C Halter, A Rudolph, P M Conneally, and T Foroud Linkage stratification and mutation analysis at the parkin locus identifies mutation positive Parkinson's disease families J. Med. Genet., July 1, 2002; 39(7): 489 - 492. [Full Text] [PDF]
|
|
|
|
|
|
H. Payami, S. Zareparsi, D. James, and J. Nutt Familial Aggregation of Parkinson Disease: A Comparative Study of Early-Onset and Late-Onset Disease Arch Neurol, May 1, 2002; 59(5): 848 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hedrich, K. Marder, J. Harris, M. Kann, T. Lynch, H. Meija-Santana, P. P. Pramstaller, E. Schwinger, S. B. Bressman, S. Fahn, et al. Evaluation of 50 probands with early-onset Parkinson's disease for Parkin mutations Neurology, April 23, 2002; 58(8): 1239 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Elbaz and A. Alperovitch Bias in Association Studies Resulting from Gene-Environment Interactions and Competing Risks Am. J. Epidemiol., February 1, 2002; 155(3): 265 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M Autere, J. S Moilanen, V. V Myllyla, and K. Majamaa Familial aggregation of Parkinson's disease in a Finnish population J. Neurol. Neurosurg. Psychiatry, July 1, 2000; 69(1): 107 - 109. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
