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Recurrent multifocal demyelinating neuropathy with febrile illness and IgG subset deficiency

From the Department of Neurology, University of Washington, Seattle, WA. Presented in part at the 50th annual meeting of the American Academy of Neurology; Minneapolis, MN; April 1998.

Address correspondence and reprint requests to Dr. Eric C. Yuen, Department of Neurology, Box 356115, University of Washington, Seattle, WA 98195.

We describe a unique syndrome of recurrent multifocal demyelinating motor greater than sensory deficits in cranial and peripheral nerve distributions with rapid, spontaneous improvement. Three patients presented with episodes over a period of 7 to 24 years, largely accompanied by febrile illness. Variably decreased IgG1 and IgG3 subclass levels were found. We postulate an immune-mediated process based upon the clinical presentation and presence of decreased IgG subclass levels.