| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Columbia-Presbyterian Medical Center (Drs. Frucht, Greene, and Fahn) and Beth Israel Medical Center (Dr. Rogers), New York, NY; and the Long Island Jewish Medical Center (Dr. Gordon), New Hyde Park, NY.
Address correspondence and reprint requests to Dr. S. Frucht, The Neurological Institute, 710 West 168th Street, New York, NY 10032.
The authors report a new side effect of the dopamine agonists pramipexole and ropinirole: sudden irresistible attacks of sleep. Eight PD patients taking pramipexole and one taking ropinirole fell asleep while driving, causing accidents. Five experienced no warning before falling asleep. The attacks ceased when the drugs were stopped. Neurologists who prescribe these drugs and patients who take them should be aware of this possible side effect.
This article has been cited by other articles:
|
|
 |
|
  C. A. Davie A review of Parkinson's disease Br. Med. Bull., June 1, 2008; 86(1): 109 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Y. Uc, M. Rizzo, S. W. Anderson, J. D. Sparks, R. L. Rodnitzky, and J. D. Dawson Impaired navigation in drivers with Parkinson's disease Brain, September 1, 2007; 130(9): 2433 - 2440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Biglan, R. G. Holloway Jr, M. P. McDermott, I. H. Richard, and The Parkinson Study Group CALM-PD Investigators Risk factors for somnolence, edema, and hallucinations in early Parkinson disease Neurology, July 10, 2007; 69(2): 187 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Thannickal, Y.-Y. Lai, and J. M. Siegel Hypocretin (orexin) cell loss in Parkinson's disease Brain, June 1, 2007; 130(6): 1586 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Gjerstad, G. Alves, T. Wentzel-Larsen, D. Aarsland, and J. P. Larsen Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology, September 12, 2006; 67(5): 853 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Dhawan, D. G. Healy, S. Pal, and K. R. Chaudhuri Sleep-related problems of Parkinson's disease. Age Ageing, May 1, 2006; 35(3): 220 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Avorn, S. Schneeweiss, L. R. Sudarsky, J. Benner, Y. Kiyota, R. Levin, and R. J. Glynn Sudden Uncontrollable Somnolence and Medication Use in Parkinson Disease Arch Neurol, August 1, 2005; 62(8): 1242 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Adler and M. J. Thorpy Sleep issues in Parkinson's disease Neurology, June 28, 2005; 64(12_suppl_3): S12 - S20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Plowman, D. T. Boggie, A. P. Morreale, M. G. Schaefer, M. L. DeLattre, and H. Chan Sleep attacks in patients receiving dopamine-receptor agonists Am. J. Health Syst. Pharm., March 1, 2005; 62(5): 537 - 540. [Full Text] [PDF]
|
|
|
|
 |
|
 A Schrag Driving in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, February 1, 2005; 76(2): 159 - 159. [Full Text] [PDF]
|
|
|
|
|
|
D. B. Rye The two faces of Eve: Dopamine's modulation of wakefulness and sleep Neurology, October 26, 2004; 63(8_suppl_3): S2 - S7. [Abstract] [Full Text]
|
|
|
|
|
|
K. R. Chaudhuri and P. Martinez-Martin Clinical assessment of nocturnal disability in Parkinson's disease: The Parkinson's Disease Sleep Scale Neurology, October 26, 2004; 63(8_suppl_3): S17 - S20. [Full Text]
|
|
|
|
|
|
A. H. Schapira Excessive daytime sleepiness in Parkinson's disease Neurology, October 26, 2004; 63(8_suppl_3): S24 - S27. [Full Text]
|
|
|
|
|
|
P. Barone, M. Amboni, C. Vitale, and V. Bonavita Treatment of nocturnal disturbances and excessive daytime sleepiness in Parkinson's disease Neurology, October 26, 2004; 63(8_suppl_3): S35 - S38. [Abstract] [Full Text]
|
|
|
|
|
|
A. Bowron Practical considerations in the use of apomorphine injectable Neurology, March 23, 2004; 62(6_suppl_4): S32 - S36. [Abstract] [Full Text]
|
|
|
|
|
|
B. Phillips Movement disorders: A sleep specialist's perspective Neurology, March 9, 2004; 62(90052): S9 - 16. [Abstract] [Full Text]
|
|
|
|
|
|
A. Razmy, A. E. Lang, and C. M. Shapiro Predictors of Impaired Daytime Sleep and Wakefulness in Patients With Parkinson Disease Treated With Older (Ergot) vs Newer (Nonergot) Dopamine Agonists Arch Neurol, January 1, 2004; 61(1): 97 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The Parkinson Study Group A Controlled Trial of Rotigotine Monotherapy in Early Parkinson's Disease Arch Neurol, December 1, 2003; 60(12): 1721 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Yale, P. Hansotia, D. Knapp, and J. Ehrfurth Neurologic Conditions: Assessing Medical Fitness to Drive Clin. Med. Res., July 1, 2003; 1(3): 177 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Merino-Andreu, I. Arnulf, E. Konofal, J. P. Derenne, and Y. Agid Unawareness of naps in Parkinson's disease and in disorders with excessive daytime sleepiness Neurology, May 13, 2003; 60(9): 1553 - 1554. [Full Text] [PDF]
|
|
|
|
|
|
K R Chaudhuri, S Pal, A DiMarco, C Whately-Smith, K Bridgman, R Mathew, F R Pezzela, A Forbes, B Hogl, and C Trenkwalder The Parkinson's disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, December 1, 2002; 73(6): 629 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. N. Homann, K. Wenzel, K. Suppan, G. Ivanic, N. Kriechbaum, R. Crevenna, and E. Ott Sleep attacks in patients taking dopamine agonists: review BMJ, June 22, 2002; 324(7352): 1483 - 1487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Pogarell, T Gasser, J J van Hilten, S Spieker, S Pollentier, D Meier, and W H Oertel Pramipexole in patients with Parkinson's disease and marked drug resistant tremor: a randomised, double blind, placebo controlled multicentre study J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 713 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Bliwise, D. B. Rye, B. Dihenia, and P. Gurecki Greater Daytime Sleepiness in Subcortical Stroke Relative to Parkinson's Disease and Alzheimer's Disease J Geriatr Psychiatry Neurol, June 1, 2002; 15(2): 61 - 67. [Abstract] [PDF]
|
|
|
|
|
|
P. E. O'Suilleabhain and R. B. Dewey Jr Contributions of Dopaminergic Drugs and Disease Severity to Daytime Sleepiness in Parkinson Disease Arch Neurol, June 1, 2002; 59(6): 986 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Frucht and C. L. Comella Sudden-Onset Sleep in Parkinson Disease JAMA, April 24, 2002; 287(16): 2076 - 2077. [Full Text] [PDF]
|
|
|
|
|
|
I. Arnulf, E. Konofal, M. Merino-Andreu, J. L. Houeto, V. Mesnage, M. L. Welter, L. Lacomblez, J. L. Golmard, J. P. Derenne, and Y. Agid Parkinson's disease and sleepiness: An integral part of PD Neurology, April 9, 2002; 58(7): 1019 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Rye and J. Jankovic Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD Neurology, February 12, 2002; 58(3): 341 - 346. [Full Text] [PDF]
|
|
|
|
|
|
J.J. Ferreira, M. Galitzky, C. Thalamas, M. Tiberge, J.L. Montastruc, C. Sampaio, and O. Rascol Effect of ropinirole on sleep onset: A randomized, placebo-controlled study in healthy volunteers Neurology, February 12, 2002; 58(3): 460 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Tan, S. Y. Lum, S. M.C. Fook-Chong, M. L. Teoh, Y. Yih, L. Tan, A. Tan, and M. C. Wong Evaluation of somnolence in Parkinson's disease: Comparison with age- and sex-matched controls Neurology, February 12, 2002; 58(3): 465 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Hubble Long-term studies of dopamine agonists Neurology, February 1, 2002; 58(90001): S42 - 50. [Abstract] [Full Text]
|
|
|
|
|
|
C. R. Cantor and M. B. Stern Dopamine agonists and sleep in Parkinson's disease Neurology, February 1, 2002; 58(90001): S71 - 78. [Abstract] [Full Text]
|
|
|
|
|
|
D. E. Hobson, A. E. Lang, W. R. W. Martin, A. Razmy, J. Rivest, and J. Fleming Excessive Daytime Sleepiness and Sudden-Onset Sleep in Parkinson Disease: A Survey by the Canadian Movement Disorders Group JAMA, January 23, 2002; 287(4): 455 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Comella Daytime Sleepiness, Agonist Therapy, and Driving in Parkinson Disease JAMA, January 23, 2002; 287(4): 509 - 511. [Full Text] [PDF]
|
|
|
|
|
|
S. Frucht, P. E. Greene, W. J. Weiner, C.W. Olanow, R.L. Watts, W.C. Koller, K. Kieburtz, and R. C. Griggs An algorithm (decision tree) for the management of Parkinson's disease (2001): Treatment guidelines Neurology, January 8, 2002; 58(1): 156 - 157. [Full Text] [PDF]
|
|
|
|
|
|
W. G. Ondo, K. Dat Vuong, H. Khan, F. Atassi, C. Kwak, and J. Jankovic Daytime sleepiness and other sleep disorders in Parkinson's disease Neurology, October 23, 2001; 57(8): 1392 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Guilleminault and S. N. Brooks Excessive daytime sleepiness: A challenge for the practising neurologist Brain, August 1, 2001; 124(8): 1482 - 1491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Olanow, R. L. Watts, and W. C. Koller An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment Neurology, June 12, 2001; 56(suppl_5): S1 - S88. [Full Text] [PDF]
|
|
|
|
|
|
K. Stiasny, J. C. Moller, and W. H. Oertel Safety of pramipexole in patients with restless legs syndrome Neurology, November 28, 2000; 55(10): 1589 - 1590. [Full Text] [PDF]
|
|
|
|
|
|
Parkinson Study Group Pramipexole vs Levodopa as Initial Treatment for Parkinson Disease: A Randomized Controlled Trial JAMA, October 18, 2000; 284(15): 1931 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Tanner Dopamine Agonists in Early Therapy for Parkinson Disease: Promise and Problems JAMA, October 18, 2000; 284(15): 1971 - 1973. [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Hiner, M. Earnhart, T. Yamamoto, S. Frucht, W. J. Weiner, S. A. Factor, O. Rascol, and The 056 Study Group Ropinirole as Compared with Levodopa in Parkinson's Disease N. Engl. J. Med., September 21, 2000; 343(12): 884 - 885. [Full Text]
|
|
|
|
|
|
I. Arnulf, A.-M. Bonnet, P. Damier, B.-P. Bejjani, D. Seilhean, J.-P. Derenne, and Y. Agid Hallucinations, REM sleep, and Parkinson's disease: A medical hypothesis Neurology, July 25, 2000; 55(2): 281 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D J BROOKS Dopamine agonists: their role in the treatment of Parkinson's disease J. Neurol. Neurosurg. Psychiatry, June 1, 2000; 68(6): 685 - 689. [Full Text] [PDF]
|
|
|
|
|
|
O. Rascol, D. J. Brooks, A. D. Korczyn, P. P. De Deyn, C. E. Clarke, A. E. Lang, and The 056 Study Group A Five-Year Study of the Incidence of Dyskinesia in Patients with Early Parkinson's Disease Who Were Treated with Ropinirole or Levodopa N. Engl. J. Med., May 18, 2000; 342(20): 1484 - 1491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-K. Tan and W. Ondo Clinical Characteristics of Pramipexole-Induced Peripheral Edema Arch Neurol, May 1, 2000; 57(5): 729 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Olanow, A. H. V. Schapira, T. Roth, W. J. Weiner, M. M. Hoehn, A. Lledo, J. Nash, F. M. Arellano, M. Corrigan, G. Arnold, et al. Falling asleep at the wheel: Motor vehicle mishaps in people taking pramipexole and ropinirole Neurology, January 11, 2000; 54(1): 274 - 274. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
