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From the Department of Health and Community Systems (Dr. Reynolds), School of Nursing; the Division of Geriatrics & Neuropsychiatry (Drs. Johnston, DeKosky, and Ganguli), Department of Psychiatry, School of Medicine; and the Department of Epidemiology (Drs. Johnston, Dodge, and Ganguli), Graduate School of Public Health, University of Pittsburgh, PA.
Address correspondence and reprint requests to Dr. Mary Ganguli, Western Psychiatric Institute and Clinic, 3811 O’Hara Street, Pittsburgh, PA 15213-2593.
The objective of this analysis was to determine the relationship, if any, of head size to performance on a cognitive screening test among elderly nondemented adults participating in a community-based survey. The study sample included 825 subjects (533 women, 292 men), age 70 to 95 years. Multivariate analyses, with adjustment for age and education, revealed that smaller head size was associated with low Mini-Mental State Examination (MMSE) scores (i.e., below the 10th percentile) in both men and women. For every 1-centimeter increment in head size, there was a corresponding reduction of \f20% in the probability of a low MMSE score.
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