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From the Section of Neuroradiology (Dr. Derdeyn) and Division of Radiological Sciences (Drs. Derdeyn, Grubb, and Powers), Mallinckrodt Institute of Radiology; and the Department of Neurology and Neurological Surgery (Drs. Grubb and Powers), Washington University School of Medicine, St. Louis, MO.
Address correspondence and reprint requests to Dr. C.P. Derdeyn, Mallinckrodt Institute of Radiology, 510 South Kingshighway Blvd., St. Louis, MO 63110.
Article Abstract
Stenosis or occlusion of the major arteries of the head and neck may cause hemodynamic impairment of the distal cerebral circulation. Hemodynamic factors may play an important role in the pathogenesis of ischemic stroke for patients with cerebrovascular disease. Several neuroimaging methods are currently available for the indirect assessment of the hemodynamic effect of atherosclerotic stenosis or occlusion on the distal cerebrovasculature. Because these methods rely on different underlying physiologic mechanisms, they are not interchangeable. Two basic categories of hemodynamic impairment can be assessed with these techniques: Stage 1, in which autoregulatory vasodilation secondary to reduced perfusion pressure is inferred by the measurement of either increased blood volume or an impaired blood flow response to a vasodilatory stimulus; and Stage 2, in which increased oxygen extraction fraction (OEF) is noninvasively but directly measured. The correlation of different Stage 1 methods with each other and with Stage 2 techniques is quite variable. Clinical studies associating different manifestations of hemodynamic impairment with stroke risk often suffer from methodologic problems. The best evidence to date for such an association is for increased OEF measured in patients with symptomatic carotid occlusion. In the absence of data demonstrating improvement in patient outcome, there is currently no role for the routine use of these tools to guide clinical management in patients with cerebrovascular disease.
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C. P. Derdeyn and N. J. Alkayed Is the Acetazolamide Test Valid for Quantitative Assessment of Maximal Cerebral Autoregulatory Vasodilation? Response Stroke, September 1, 2000; 31 (9): 2266 - 2278. [Full Text] [PDF]
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