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Neurology 1999;53:416
© 1999 American Academy of Neurology
Brief Communications

Prevalence and severity of dementia among northern Italian centenarians

G. Ravaglia, MD, P. Forti, MD, D. De Ronchi, MD, F. Maioli, MD, B. Nesi, MD, D. Cucinotta, MD, M. Bernardi, MD and G. Cavalli, MD

From the Department of Internal Medicine, Cardioangiology, and Hepatology (Drs. Ravaglia, Forti, Maioli, Nesi, Bernardi, and Cavalli), the Division of Geriatric Medicine (Dr. Cucinotta), S. Orsola-Malpighi Hospital; and the Institute of Psychiatry (Dr. De Ronchi), University of Bologna, Italy.

Address correspondence and reprint requests to Dr. Giovanni Ravaglia, Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Policlinico S. Orsola, Università di Bologna, Via Massarenti, 9, 40138 Bologna, Italy.

Using diagnostic criteria from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, dementia was clinically diagnosed in 57 (62%) of 92 centenarians living in two northern Italian provinces. The condition was severely disabling in approximately 70% of the demented patients. Although clinically diagnosed AD accounted for 79% of dementia cases, almost one third of patients with AD had risk factors for vascular dementia, suggesting that the aging brain may be susceptible to multiple additive factors that impair cognition.




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