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Coexistence of temporal lobe and idiopathic generalized epilepsies

From the Departments of Clinical Neurophysiology (Drs. Koutroumanidis, Hennessy, Elwes, and Binnie) and Neurosurgery (Dr. Polkey) King’s College Hospital, London, UK.

Address correspondence and reprint requests to Dr. Michael Koutroumanidis, Department of Clinical Neurophysiology, Mapother House, King’s College Hospital, London SE5 9RS, UK.

OBJECTIVE: To assess the interrelation of idiopathic generalized epilepsy (IGE) and temporal lobe epilepsy (TLE) when they coexist in the same patient.

METHODS: The authors reviewed the electroclinical features of 350 consecutive patients who had temporal resection between 1975 and 1997 at the Maudsley and King’s College Hospitals, London.

RESULTS: Two patients had the unusual combination of TLE and IGE (0.57%). In the first, the clinical onset of juvenile myoclonic epilepsy followed the surgical resolution of his partial seizures but had been heralded for at least 5 years by subclinical spontaneous and photically induced generalized spike–wave discharges. In the second, TLE and juvenile absence epilepsy had a long parallel course before surgery. After surgery he had no further partial seizures.

CONCLUSION: These cases suggest that when an idiopathic absence or myoclonic syndrome manifests in a patient with symptomatic TLE, the phenotype may not be a merged syndrome. Rather, the two conditions can retain their inherent electroclinical profile, responsiveness to treatment, and prognosis.

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