Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuzniecky, R.
Right arrow Articles by Hugg, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuzniecky, R.
Right arrow Articles by Hugg, J.
Neurology 1999;53:496
© 1999 American Academy of Neurology
Articles

Quantitative MRI in temporal lobe epilepsy

Evidence for fornix atrophy

R. Kuzniecky, MD, E. Bilir, MD, F. Gilliam, MD, E. Faught, MD, R. Martin, PhD and J. Hugg, PhD

From the UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham.

Address correspondence and reprint requests to Dr. Ruben Kuzniecky, Department of Neurology, UAB Station, Birmingham, AL 35294.

OBJECTIVE: To investigate whether the fornix and mamillary bodies, being part of the limbic system, are abnormal in patients with mesial temporal lobe epilepsy (MTLE).

BACKGROUND: The limbic system comprises the hippocampal formation, fornix, mamillary bodies, thalamus, and other integrated structures. This system is implicated in complex functions, including memory and emotion, and in diseases such as MTLE.

METHODS: The authors performed volumetric measurements of hippocampus, amygdala, fornix, and mamillary bodies in 50 patients with MTLE and compared the results with normal controls and patients with extratemporal lobe epilepsy.

RESULTS: Control (n = 17) measurements of the amygdala, hippocampus, and fornix revealed larger volumes of the right hemisphere structures (p < 0.001). Normalized fornix volumes revealed atrophy in 86% of studies concordant with hippocampal atrophy in all cases but one. Similarly, the mean hippocampal and fornix volumes for the group discriminated the epileptogenic temporal lobe (p < 0.001). Limbic volumes were normal in all patients with extratemporal lobe epilepsy.

CONCLUSIONS: Quantitative MRI findings support the concept that MTLE is not a process limited to the hippocampus but also involves other interrelated limbic system structures, in particular, the fornix.




This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L Concha, C Beaulieu, D L Collins, and D W Gross
White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis
J. Neurol. Neurosurg. Psychiatry, March 1, 2009; 80(3): 312 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
L. Concha, D. W. Gross, and C. Beaulieu
Diffusion Tensor Tractography of the Limbic System
AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2267 - 2274.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
P. M. G. Pereira, R. Insausti, E. Artacho-Perula, T. Salmenpera, R. Kalviainen, and A. Pitkanen
MR Volumetric Analysis of The Piriform Cortex and Cortical Amygdala in Drug-Refractory Temporal Lobe Epilepsy
AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 319 - 332.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. S. Briellmann, G. D. Jackson, G. S. Pell, L. A. Mitchell, and D. F. Abbott
Structural abnormalities remote from the seizure focus: A study using T2 relaxometry at 3 T
Neurology, December 28, 2004; 63(12): 2303 - 2308.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. G. Burneo, R. I. Kuzniecky, M. Bebin, and R. C. Knowlton
Cortical reorganization in malformations of cortical development: A magnetoencephalographic study
Neurology, November 23, 2004; 63(10): 1818 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. G. Burneo, E. Bilir, E. Faught, R. Morawetz, R. C. Knowlton, R. Martin, and R. I. Kuzniecky
Significance of Fornix Atrophy in Temporal Lobe Epilepsy Surgery Outcome
Arch Neurol, September 1, 2003; 60(9): 1238 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
P. Vermathen, K. D. Laxer, N. Schuff, G. B. Matson, and M. W. Weiner
Evidence of Neuronal Injury Outside the Medial Temporal Lobe in Temporal Lobe Epilepsy: N-Acetylaspartate Concentration Reductions Detected with Multisection Proton MR Spectroscopic Imaging--Initial Experience
Radiology, January 1, 2003; 226(1): 195 - 202.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. Coste, P. Ryvlin, M. Hermier, K. Ostrowsky, P. Adeleine, J. C. Froment, and F. Mauguiere
Temporopolar changes in temporal lobe epilepsy: A quantitative MRI-based study
Neurology, September 24, 2002; 59(6): 855 - 861.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. C. Martin, S. M. Sawrie, R. C. Knowlton, E. Bilir, F. G. Gilliam, E. Faught, R. B. Morawetz, and R. Kuzniecky
Bilateral hippocampal atrophy: Consequences to verbal memory following temporal lobectomy
Neurology, August 28, 2001; 57(4): 597 - 604.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A Colchester, D Kingsley, D Lasserson, B Kendall, F Bello, C Rush, T G Stevens, G Goodman, G Heilpern, N Stanhope, et al.
Structural MRI volumetric analysis in patients with organic amnesia, 1: methods and comparative findings across diagnostic groups
J. Neurol. Neurosurg. Psychiatry, July 1, 2001; 71(1): 13 - 22.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by AAN Enterprises, Inc.