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Neurology 1999;53:642
© 1999 American Academy of Neurology
Brief Communications

No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

C.-J. Hu, MD, S.-M. Sung, MD, H.-C. Liu, MD, K.-Y. Lee, MD, W.-C. Hsu, MT, W.-K. Wong, MD, C.-C. Lee, MD, C.-H. Tsai, MD and J.-G. Chang, MD

From the Department of Neurology, Molecular Medicine (Drs. Hu and K.-Y. Lee), Family Medicine (Dr. Wong), Taipei Municipal Jen-Ai Hospital; Taipei City Psychiatry Center (Drs. Sung and Liu); Graduated Institute of Biomedical Technology (W.-C. Hsu), Taipei Medical College; Division of Molecular Medicine, Department of Medical Research (Drs. C.-C. Lee, Tsai, and Chang), China Medical College Hospital, Taiwan.

Address correspondence and reprint requests to Dr. Jan-Gowth Chang, Division of Molecular Medicine, Department of Medical Research, China Medical College Hospital, 2, Yu-Der Road, Taichung, Taiwan.

The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.




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