Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuzniecky, R.
Right arrow Articles by Gilliam, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuzniecky, R.
Right arrow Articles by Gilliam, F.
Neurology 1999;53:694
© 1999 American Academy of Neurology
Articles

Predictive value of 1H MRSI for outcome in temporal lobectomy

R. Kuzniecky, MD, J. Hugg, PhD, H. Hetherington, PhD, R. Martin, PhD, E. Faught, MD, R. Morawetz, MD and F. Gilliam, MD

From the Departments of Neurology and Neurosurgery, UAB Epilepsy Center, University of Alabama at Birmingham.

Address correspondence and reprint requests to Dr. Ruben Kuzniecky, Department of Neurology, UAB Station, Birmingham, AL 35294-0021.

OBJECTIVE: To investigate the predictive value of 1H MRSI for outcome in patients with mesial temporal lobe epilepsy (MTLE).

BACKGROUND: 1H MRSI has been shown to be highly sensitive in the lateralization of temporal lob epilepsy.

METHODS: The authors analyzed the relationship between the 1H MRSI findings and surgical outcome in 40 consecutive patients who underwent temporal lobe surgery for MTLE. Outcome at a mean of 24 months (range 18 to 40 months) was classified as seizure free or not seizure free.

RESULTS: At follow-up, 78% of patients were seizure free. Correlations showed no predictive value for the creatine/N-acetylated compound (Cr/NA) ratio of the operated temporal lobe and outcome. However, a relationship was found between surgical failure and the Cr/NA ratio of the nonoperated temporal lobe and with a Cr/NA ratio in the nonoperated lobe above 1.21 in patients with bilateral abnormalities (p < 0.01).

CONCLUSIONS: Preoperative elevations in the Cr/NA ratio in the nonoperated temporal lobe or the presence of higher metabolic ratios contralateral to the proposed surgery are associated with surgical failure. The predictive value of 1H MRSI absolute metabolite concentrations for outcome in MTLE requires further investigation.

Key words: MRS image—Temporal lobe epilepsy—Outcome.




This article has been cited by other articles:


Home page
 NeurologyHome page
H. P. Hetherington, R. I. Kuzniecky, K. Vives, O. Devinsky, S. Pacia, D. Luciano, B. Vasquez, S. Haut, D. D. Spencer, and J. W. Pan
A subcortical network of dysfunction in TLE measured by magnetic resonance spectroscopy
Neurology, December 11, 2007; 69(24): 2256 - 2265.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
F. G. Gilliam, B. M. Maton, R. C. Martin, S. M. Sawrie, R. E. Faught, J. W. Hugg, M. Viikinsalo, and R. I. Kuzniecky
Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy
Neurology, January 30, 2007; 68(5): 364 - 368.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
F. S. Machado, M. S. Desruisseaux, Nagajyothi, R. P. Kennan, H. P. Hetherington, M. Wittner, L. M. Weiss, S. C. Lee, P. E. Scherer, M. Tsuji, et al.
Endothelin in a murine model of cerebral malaria.
Experimental Biology and Medicine, June 1, 2006; 231(6): 1176 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
P.M. G. Pereira, E. Oliveira, and P. Rosado
Apparent Diffusion Coefficient Mapping of the Hippocampus and the Amygdala in Pharmaco-Resistant Temporal Lobe Epilepsy
AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 671 - 683.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
E. Pataraia, P.G. Simos, E.M. Castillo, R.L. Billingsley, S. Sarkari, J.W. Wheless, V. Maggio, W. Maggio, J.E. Baumgartner, P.R. Swank, et al.
Does magnetoencephalography add to scalp video-EEG as a diagnostic tool in epilepsy surgery?
Neurology, March 23, 2004; 62(6): 943 - 948.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
M. P Richardson
Epilepsy and surgical mapping
Br. Med. Bull., March 1, 2003; 65(1): 179 - 192.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
E. L. So
Role of Neuroimaging in the Management of Seizure Disorders
Mayo Clin. Proc., November 1, 2002; 77(11): 1251 - 1264.
[Abstract] [PDF]

Home page
 NeurologyHome page
K. Kantarci, C. Shin, J. W. Britton, E. L. So, G. D. Cascino, and C. R. Jack Jr.
Comparative diagnostic utility of 1H MRS and DWI in evaluation of temporal lobe epilepsy
Neurology, June 25, 2002; 58(12): 1745 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. B. Antel, L. M. Li, F. Cendes, D. L. Collins, R. E. Kearney, R. Shinghal, and D. L. Arnold
Predicting surgical outcome in temporal lobe epilepsy patients using MRI and MRSI
Neurology, May 28, 2002; 58(10): 1505 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. Suhy, K.D. Laxer, A.A. Capizzano, P. Vermathen, G.B. Matson, N.M. Barbaro, and M.W. Weiner
1H MRSI predicts surgical outcome in MRI-negative temporal lobe epilepsy
Neurology, March 12, 2002; 58(5): 821 - 823.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
C. P. Doherty, A. J. Cole, F. Cendes, F. Andermann, and F. Dubeau
The Requirement for Ictal EEG Recordings Prior to Temporal Lobe Epilepsy Surgery
Arch Neurol, April 1, 2001; 58(4): 678 - 680.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by AAN Enterprises, Inc.