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Neurology 1999;53:852
© 1999 American Academy of Neurology
Brief Communications

A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer

F. Ferracci, MD, G. Fassetta, MD, M. H. Butler, PhD, S. Floyd, M. Solimena, MD and P. De Camilli, MD

From the Department of Neurology (Drs. Ferracci and Fassetta), Ospedale di Belluno, Belluno, Italy; the Department of Cell Biology and Howard Hughes Medical Institute (Drs. Butler, Floyd, and De Camilli) and the Department of Internal Medicine, Section of Endocrinology (Dr. Solimena), Yale University, New Haven, CT.

Address correspondence and reprint requests to Dr. Franco Ferracci, Reparto di Neurologia, Ospedale di Belluno, Viale Europa, 32100 Belluno, Italy.

A 72-year-old woman developed a lower motor neuron syndrome (MNS) 4 months before the appearance of breast cancer. Monoparesis progressed to quadriparesis despite high-dose IV immunoglobulins, plasma exchange, and azathioprine, and high-dose IV methylprednisolone. The patient improved only after the removal of the tumor. MRI demonstrated hyperintensities in the cervical spinal cord. The patient had antibodies that reacted with axonal initial segments and nodes of Ranvier. The findings suggest that in this patient lower MNS may be a paraneoplastic condition associated with breast cancer.

Key words: Antineuronal antibody—Motor neuron syndrome—Breast cancer.




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