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Neurology 1999;53:861
© 1999 American Academy of Neurology
Brief Communications

Neurologic complications associated with hepatitis C virus infection

J. I. Tembl, MD, J. M. Ferrer, MD, M. T. Sevilla, MD, A. Lago, MD, F. Mayordomo, MD and J. J. Vilchez, MD

From the Departments of Neurology (Drs. Tembl, Ferrer, Sevilla, Lago, and Vilchez) and Pathology (Dr. Mayordomo), Hospital Universitari La Fe, Valencia, Spain.

Address correspondence and reprint requests to Dr. Jan J. Vilchez, Department of Neurology, Hospital Universitari La Fe, Av. Campanar 21, E-46009 Valencia, Spain.

A series of nine patients with neurologic complications of hepatitis C virus infection is reported. Seven patients presented a combination of chronic sensory polyneuropathy, multineuropathy, and encephalopathy related to cryoglobulinemia. The noncryoglobulinemic symptoms consisted of an anterior optic neuropathy and a restless legs syndrome with small-fiber neuropathy. Corticosteroids and cyclophosphamide were useful in controlling vasculitic episodes. Interferon-{alpha} caused remission in half of the treated patients.

Key words: Hepatitis C infection—Neurologic complications.




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