Neurology
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Neurology 1999;53:1128
© 1999 American Academy of Neurology
Brief Communications

Stroke after zoster ophthalmicus in a 12-year-old girl with protein C deficiency

D. Cadavid, MD, P. L. Pearl, MD, E. C. Dubovsky, MD, A. Angiolillo, MD and L. G. Vezina, MD

From the Departments of Neurology (Drs. Cadavid and Pearl), Radiology (Drs. Dubovsky and Vezina), and Hematology/Oncology (Dr. Angiolillo), Children’s National Medical Center, George Washington University School of Medicine, Washington, DC.

Address correspondence and reprint requests to Dr. Phillip L. Pearl, Department of Neurology, Children’s National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010.

A 12-year-old girl who had zoster ophthalmicus 10 months earlier presented with hemiparesis and corresponding basal ganglionic infarction related to middle cerebral artery branch thrombosis ipsilateral to the zoster. Hematologic evaluation disclosed protein C deficiency. This represents the first zoster-associated stroke reported in childhood associated with protein C deficiency, with extension of the latency period between zoster and infarction, previously reported to be 6 months.

Key words: Stroke—Zoster ophthalmicus—Protein C deficiency.






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