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Neurology 1999;53:1135
© 1999 American Academy of Neurology
Brief Communications

MRI detection of new hemorrhages: Potential marker of progression in cerebral amyloid angiopathy

Steven M. Greenberg, MD, PhD, Heather C. O’Donnell, BA, Pamela W. Schaefer, MD and Eduard Kraft, MD

From the Department of Neurology (Dr. Greenberg and H.C. O’Donnell), NMR Center (Dr. Kraft), Department of Radiology, and Division of Neuroradiology (Dr. Schaefer), Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Address correspondence and reprint requests to Dr. Steven M. Greenberg, Wang ACC 836, Massachusetts General Hospital, Boston, MA 02114.

The authors used serial gradient-echo MRIs to detect new small hemorrhages in patients with previous lobar hemorrhage. Of 24 lobar hemorrhage patients (17 diagnosed with probable and 7 with possible amyloid angiopathy) who prospectively underwent repeat MRI 1.5 years after initial study, 9 (38%) demonstrated additional hemorrhages at follow-up. Interrater agreement was high. New hemorrhages were more frequent in patients with probable amyloid angiopathy (8 of 17, 47%) with more hemorrhages at baseline (p < 0.01). These results suggest a role for gradient-echo MRI in assessing disease progression in amyloid angiopathy.

Key words: Hemorrhage—Amyloid angiopathy—MRI—Noninvasive.




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Home page
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