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Neurology 1999;53:1146
© 1999 American Academy of Neurology
Brief Communications

No association of paraoxonase gene polymorphism with atherosclerosis or Alzheimer’s disease

N. Sodeyama, MD, PhD, M. Yamada, MD, PhD, Y. Itoh, MD, PhD, N. Suematsu, MD, PhD, M. Matsushita, MD, PhD, E. Otomo, MD, PhD and H. Mizusawa, MD, PhD

From the Department of Neurology (Drs. Sodeyama, Yamada, and Mizusawa), Tokyo Medical and Dental University; the Departments of Internal Medicine (Drs. Itoh and Otomo) and Pathology (Dr. Suematsu), Yokufukai Geriatric Hospital; and the Department of Neuropathology (Dr. Matsushita), Tokyo Institute of Psychiatry, Tokyo, Japan.

Address correspondence and reprint requests to Dr. Masahito Yamada, Department of Neurology, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan; e-mail: m-yamada.nuro@ med.tmd.ac.jp

Both AD and paraoxonase (PON) have been reported to be related to lipids and atherosclerosis, suggesting that the PON gene (PON) is a possible genetic risk factor for AD. We found no association of PON polymorphism with severity of atherosclerosis, densities of AD-type, neuropathologic change, or development of AD in 47 AD and 90 nondemented patients. Our study suggests that PON polymorphism does not play a causal role in the development of atherosclerosis or AD.

Key words: AD—Paraoxonase—Polymorphism—Neuropathologic change.




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