Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, H. C.
Right arrow Articles by Teng, E. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, H. C.
Right arrow Articles by Teng, E. L.
Neurology 1999;53:962
© 1999 American Academy of Neurology
Articles

ApoE genotype in relation to AD and cholesterol

A study of 2,326 Chinese adults

H. C. Liu, MD, C. J. Hong, MD, S. J. Wang, MD, J. L. Fuh, MD, P. N. Wang, MD, H. Y. Shyu, MD and E. L. Teng, PhD

From the The Neurological Institute (Drs. Liu, Wang, Fuh, Wang, and Shyu) and Department of Psychiatry (Dr. Hong), Veterans General Hospital-Taipei and National Yang-Ming University School of Medicine, Taipei, Taiwan; and the Department of Neurology (Dr. Teng), University of Southern California School of Medicine, Los Angeles, CA.

Address correspondence and reprint requests to Dr. Hsiu-Chih Liu, The Neurological Institute, Veterans General Hospital-Taipei, Taipei, Taiwan; e-mail: hcliu{at}vghtpe.gov.tw

OBJECTIVE: To calculate the frequencies of apolipoprotein E (apoE) alleles in a large Chinese community sample and to compare the serum cholesterol levels of {epsilon}2, {epsilon}3, and {epsilon}4 carriers.

BACKGROUND: In comparison with Western populations, a lower frequency of the apoE {epsilon}4 allele among the Chinese has been proposed as one factor for the lower prevalence of AD found in Chinese populations, but there are insufficient Chinese data on {epsilon}4 frequency that are based on large community samples. In addition, although Western studies have repeatedly found a lower cholesterol level in {epsilon}2 carriers and a higher cholesterol level in {epsilon}4 carriers in comparison with {epsilon}3 homozygotes, two Chinese studies have yielded inconsistent findings between them.

METHODS: During the incidence phase of an epidemiologic survey of several neurologic disorders in a Chinese community, the authors took blood samples from 2,326 participants to determine the apoE genotypes and to measure cholesterol levels.

RESULTS: The allelic frequencies of {epsilon}2, {epsilon}3, and {epsilon}4 were 11.8%, 76.4%, and 11.8% among 17 AD patients, and 7.8%, 84.1%, and 8.1% for the entire sample. The mean cholesterol level of the {epsilon}2 carriers was significantly lower, and that of the {epsilon}4 carriers significantly higher, than that of the {epsilon}3 homozygotes.

CONCLUSIONS: The obtained {epsilon}4 rate of 8.1% is lower than most of the Western findings, and this may account in part for the lower prevalence of AD found among the Chinese. The associations between the apoE genotype and serum cholesterol level are similar between Chinese and white populations.

Key words: Apolipoprotein E—Alzheimer’s disease—Cholesterol—Chinese.




This article has been cited by other articles:


Home page
 NeurologyHome page
C. Tzourio, H. Arima, S. Harrap, C. Anderson, O. Godin, M. Woodward, B. Neal, M-G Bousser, J. Chalmers, F. Cambien, et al.
APOE genotype, ethnicity, and the risk of cerebral hemorrhage
Neurology, April 15, 2008; 70(16): 1322 - 1328.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
D. C. Ewbank
Differences in the Association Between Apolipoprotein E Genotype and Mortality Across Populations
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2007; 62(8): 899 - 907.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
H.-C. Liu, P.-N. Wang, H.-C. Wang, K.-N. Lin, C.-J. Hong, C.-Y. Liu, and P.-H. Tsai
Conversion to Dementia From Questionable Dementia in an Ethnic Chinese Population
J Geriatr Psychiatry Neurol, June 1, 2007; 20(2): 76 - 83.
[Abstract] [PDF]

Home page
 Mol. Endocrinol.Home page
K. D. Whitney, M. A. Watson, J. L. Collins, W. G. Benson, T. M. Stone, M. J. Numerick, T. K. Tippin, J. G. Wilson, D. A. Winegar, and S. A. Kliewer
Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System
Mol. Endocrinol., June 1, 2002; 16(6): 1378 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
C.-Y. Liu, C.-J. Hong, T.-Y. Liu, K.-N. Lin, P.-N. Wang, C.-W. Chi, Y.-Y. Chuang, and H.-C. Liu
Lack of Association between the Apolipoprotein E Genotype and Depression in Alzheimer's Disease
J Geriatr Psychiatry Neurol, April 1, 2002; 15(1): 20 - 23.
[Abstract] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
W. Reynish, S. Andrieu, F. Nourhashemi, and B. Vellas
Nutritional Factors and Alzheimer's Disease
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2001; 56(11): M675 - 680.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. W. Knittweis, W. A. McMullen, S. N. Romas, R. Mayeux, A. J. C. Slooter, A. Ruitenberg, C. M. van Duijn, M. M. B. Breteler, and H. C. Liu
The effect of apoE on dementia is not through atherosclerosis: The Rotterdam Study
Neurology, June 27, 2000; 54(12): 2356 - 2358.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by AAN Enterprises, Inc.