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Neurology 1999;53:962
© 1999 American Academy of Neurology
Articles

ApoE genotype in relation to AD and cholesterol

A study of 2,326 Chinese adults

H. C. Liu, MD, C. J. Hong, MD, S. J. Wang, MD, J. L. Fuh, MD, P. N. Wang, MD, H. Y. Shyu, MD and E. L. Teng, PhD

From the The Neurological Institute (Drs. Liu, Wang, Fuh, Wang, and Shyu) and Department of Psychiatry (Dr. Hong), Veterans General Hospital-Taipei and National Yang-Ming University School of Medicine, Taipei, Taiwan; and the Department of Neurology (Dr. Teng), University of Southern California School of Medicine, Los Angeles, CA.

Address correspondence and reprint requests to Dr. Hsiu-Chih Liu, The Neurological Institute, Veterans General Hospital-Taipei, Taipei, Taiwan; e-mail: hcliu{at}vghtpe.gov.tw

OBJECTIVE: To calculate the frequencies of apolipoprotein E (apoE) alleles in a large Chinese community sample and to compare the serum cholesterol levels of {epsilon}2, {epsilon}3, and {epsilon}4 carriers.

BACKGROUND: In comparison with Western populations, a lower frequency of the apoE {epsilon}4 allele among the Chinese has been proposed as one factor for the lower prevalence of AD found in Chinese populations, but there are insufficient Chinese data on {epsilon}4 frequency that are based on large community samples. In addition, although Western studies have repeatedly found a lower cholesterol level in {epsilon}2 carriers and a higher cholesterol level in {epsilon}4 carriers in comparison with {epsilon}3 homozygotes, two Chinese studies have yielded inconsistent findings between them.

METHODS: During the incidence phase of an epidemiologic survey of several neurologic disorders in a Chinese community, the authors took blood samples from 2,326 participants to determine the apoE genotypes and to measure cholesterol levels.

RESULTS: The allelic frequencies of {epsilon}2, {epsilon}3, and {epsilon}4 were 11.8%, 76.4%, and 11.8% among 17 AD patients, and 7.8%, 84.1%, and 8.1% for the entire sample. The mean cholesterol level of the {epsilon}2 carriers was significantly lower, and that of the {epsilon}4 carriers significantly higher, than that of the {epsilon}3 homozygotes.

CONCLUSIONS: The obtained {epsilon}4 rate of 8.1% is lower than most of the Western findings, and this may account in part for the lower prevalence of AD found among the Chinese. The associations between the apoE genotype and serum cholesterol level are similar between Chinese and white populations.

Key words: Apolipoprotein E—Alzheimer’s disease—Cholesterol—Chinese.




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