Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCarron, M. O.
Right arrow Articles by Alberts, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCarron, M. O.
Right arrow Articles by Alberts, M. J.
Neurology 1999;53:1308
© 1999 American Academy of Neurology
Articles

APOE genotype as a risk factor for ischemic cerebrovascular disease

A meta-analysis

Mark O. McCarron, MA, MRCP, David Delong, PhD and Mark J. Alberts, MD

From the Department of Neurology (Dr. McCarron), Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK; and the Divisions of Biometry (Dr. Delong) and Neurology (Dr. Alberts), Duke University Medical Center, Durham, NC.

Address correspondence and reprint requests to Dr. Mark McCarron, Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, G51 4TF, Scotland, UK; e-mail: mmc18f{at}clinmed.gla.ac.uk

OBJECTIVE: To determine whether a specific apolipoprotein E (APOE) polymorphism is a risk factor for ischemic cerebrovascular disease (CVD; stroke or TIA).

BACKGROUND: The APOE {epsilon}4 allele is overrepresented in AD, atherosclerosis, and ischemic heart disease. In addition, {epsilon}4 carriers have higher plasma cholesterol levels than non-{epsilon}4 carriers.

METHODS: Using Medline (OVID and PubMed), a search was performed for all studies that examined APOE in ischemic CVD. The authors identified nine case–control studies that were suitable for analysis.

RESULTS: There were 926 patients with ischemic stroke or TIAs and 890 age- and sex-matched control subjects. Overall analysis revealed a significantly higher APOE-{epsilon}4 allelic frequency in affected patients compared with control subjects (0.14 versus 0.09; odds ratio, 1.68; 95% CI, 1.36 to 2.09; p < 0.001 ). There was a significant excess of the {epsilon}3 allele (0.85 versus 0.80) but not the {epsilon}2 allele (0.06 versus 0.06) in the control subjects compared with the ischemic CVD patients. Seven studies had data on APOE genotypes. Carriers of {epsilon}4 were more frequent among ischemic CVD patients than control subjects (27% versus 18%; odds ratio, 1.73; 95% CI, 1.34 to 2.23; p < 0.001).

CONCLUSIONS: The APOE-{epsilon}4 allele and carriers of {epsilon}4 are more frequent among patients with ischemic CVD compared with control subjects. The {epsilon}2 allele does not appear to be protective for ischemic CVD. These findings imply a role for the APOE genotype in the pathogenesis of some cases of ischemic CVD.

Key words: Apolipoprotein E—Ischemic cerebrovascular disease.




This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
J. P. A. Ioannidis
Effect of Formal Statistical Significance on the Credibility of Observational Associations
Am. J. Epidemiol., August 15, 2008; 168(4): 374 - 383.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
F. Irie, K. H. Masaki, H. Petrovitch, R. D. Abbott, G. W. Ross, D. R. Taaffe, L. J. Launer, and L. R. White
Apolipoprotein E {varepsilon}4 Allele Genotype and the Effect of Depressive Symptoms on the Risk of Dementia in Men: The Honolulu-Asia Aging Study
Arch Gen Psychiatry, August 1, 2008; 65(8): 906 - 912.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
G. Liew, A. Shankar, J. J. Wang, R. Klein, M. S. Bray, D. J. Couper, A. R. Sharrett, and T. Y. Wong
Apolipoprotein E Gene Polymorphisms and Retinal Vascular Signs: The Atherosclerosis Risk in Communities (ARIC) Study
Arch Ophthalmol, June 1, 2007; 125(6): 813 - 818.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
W. Lalouschek, G. Endler, M. Schillinger, K. Hsieh, W. Lang, S. Cheng, P. Bauer, O. Wagner, and C. Mannhalter
Candidate Genetic Risk Factors of Stroke: Results of a Multilocus Genotyping Assay
Clin. Chem., April 1, 2007; 53(4): 600 - 605.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
M. M. Kuroda, M. E. Weck, J. F. Sarwark, A. Hamidullah, and M. S. Wainwright
Association of Apolipoprotein E Genotype and Cerebral Palsy in Children
Pediatrics, February 1, 2007; 119(2): 306 - 313.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
N. Stakias, P. Liakos, E. Tsiapali, M. Goutou, and G. N. Koukoulis
Lower Prevalence of Epsilon 4 Allele of Apolipoprotein E Gene in Healthy, Longer-Lived Individuals of Hellenic Origin
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2006; 61(12): 1228 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
T. Y. Wong, R. Klein, C. Sun, P. Mitchell, D. J. Couper, H. Lai, L. D. Hubbard, A. R. Sharrett, and for the Atherosclerosis Risk in Communities Study
Age-Related Macular Degeneration and Risk for Stroke
Ann Intern Med, July 18, 2006; 145(2): 98 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. W. Mahley, K. H. Weisgraber, and Y. Huang
Inaugural Article: Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
PNAS, April 11, 2006; 103(15): 5644 - 5651.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. Sudlow, N. A. Martinez Gonzalez, J. Kim, and C. Clark
Does Apolipoprotein E Genotype Influence the Risk of Ischemic Stroke, Intracerebral Hemorrhage, or Subarachnoid Hemorrhage?: Systematic Review and Meta-Analyses of 31 Studies Among 5961 Cases and 17 965 Controls
Stroke, February 1, 2006; 37(2): 364 - 370.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
G. Bartzokis, P. H. Lu, D. H. Geschwind, N. Edwards, J. Mintz, and J. L. Cummings
Apolipoprotein E Genotype and Age-Related Myelin Breakdown in Healthy Individuals: Implications for Cognitive Decline and Dementia
Arch Gen Psychiatry, January 1, 2006; 63(1): 63 - 72.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. G. Yip, A. C. McKee, R. C. Green, J. Wells, H. Young, L. A. Cupples, and L. A. Farrer
APOE, vascular pathology, and the AD brain
Neurology, July 26, 2005; 65(2): 259 - 265.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J.A. Schneider, J.L. Bienias, R.S. Wilson, E. Berry-Kravis, D.A. Evans, and D.A. Bennett
The Apolipoprotein E {epsilon}4 Allele Increases the Odds of Chronic Cerebral Infarction Detected at Autopsy in Older Persons
Stroke, May 1, 2005; 36(5): 954 - 959.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
L. S. Honig, W. Kukull, and R. Mayeux
Atherosclerosis and AD: Analysis of data from the US National Alzheimer's Coordinating Center
Neurology, February 8, 2005; 64(3): 494 - 500.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P D Leclercq, L S Murray, C Smith, D I Graham, J A R Nicoll, and S M Gentleman
Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype
J. Neurol. Neurosurg. Psychiatry, February 1, 2005; 76(2): 229 - 233.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A.J. C. Slooter, M. Cruts, A. Hofman, P. J. Koudstaal, D. van der Kuip, M.A. J. de Ridder, J.C. M. Witteman, M.M. B. Breteler, C. Van Broeckhoven, and C. M. van Duijn
The impact of APOE on myocardial infarction, stroke, and dementia: The Rotterdam Study
Neurology, April 13, 2004; 62(7): 1196 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
G. D. Smith and S. Ebrahim
Mendelian randomization: prospects, potentials, and limitations
Int. J. Epidemiol., February 1, 2004; 33(1): 30 - 42.
[Full Text] [PDF]

Home page
 StrokeHome page
A. Pezzini, M. Grassi, E. Del Zotto, E. Bazzoli, S. Archetti, D. Assanelli, N. M. Akkawi, A. Albertini, and A. Padovani
Synergistic Effect of Apolipoprotein E Polymorphisms and Cigarette Smoking on Risk of Ischemic Stroke in Young Adults
Stroke, February 1, 2004; 35(2): 438 - 442.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. W. Gaynor, M. Gerdes, E. H. Zackai, J. Bernbaum, G. Wernovsky, R. R. Clancy, M. F. Newman, A. M. Saunders, P. J. Heagerty, J. A. D'Agostino, et al.
Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery
J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1736 - 1745.
[Abstract] [Full Text] [PDF]

Home page
 Psychosom. Med.Home page
A. F. Jorm, M. Prior, A. Sanson, D. Smart, Y. Zhang, and S. Easteal
Apolipoprotein E Genotype and Temperament: A Longitudinal Study From Infancy to the Late Teens
Psychosom Med, July 1, 2003; 65(4): 662 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. Diaz-Arrastia, Y. Gong, S. Fair, K. D. Scott, M. C. Garcia, M. C. Carlile, M. A. Agostini, and P. C. Van Ness
Increased Risk of Late Posttraumatic Seizures Associated With Inheritance of APOE{epsilon}4 Allele
Arch Neurol, June 1, 2003; 60(6): 818 - 822.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
G. D. Kolovou, D. Ch. Daskalova, M. Hatzivassiliou, N. Yiannakouris, N. D. Pilatis, M. Elisaf, D. P. Mikhailidis, M. A. Cariolou, and D. V. Cokkinos
The Epsilon 2 and 4 Alleles of Apolipoprotein E and Ischemic Vascular Events in the Greek Population -- Implications for the Interpretation of Similar Studies
Angiology, January 1, 2003; 54(1): 51 - 58.
[Abstract] [PDF]

Home page
 ANGIOLOGYHome page
G. Kolovou, D. Daskalova, and D. P. Mikhailidis
Apolipoprotein E Polymorphism and Atherosclerosis
Angiology, January 1, 2003; 54(1): 59 - 71.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
C. Enzinger, S. Ropele, S. Strasser-Fuchs, P. Kapeller, H. Schmidt, B. Poltrum, R. Schmidt, H.-P. Hartung, and F. Fazekas
Lower Levels of N-Acetylaspartate in Multiple Sclerosis Patients With the Apolipoprotein E {epsilon}4 Allele
Arch Neurol, January 1, 2003; 60(1): 65 - 70.
[Abstract] [Full Text] [PDF]

Home page
 GerontologistHome page
G. G. Fillenbaum, D. G. Blazer, B. M. Burchett, A. M. Saunders, and D. H. Taylor Jr.
Apolipoprotein E {varepsilon}4 and Risk of Mortality in African American and White Older Community Residents
Gerontologist, June 1, 2002; 42(3): 381 - 386.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A.J.C. Slooter, M. L. Bots, L. M. Havekes, A. I. del Sol, M. Cruts, D. E. Grobbee, A. Hofman, C. Van Broeckhoven, J.C.M. Witteman, and C. M. van Duijn
Apolipoprotein E and Carotid Artery Atherosclerosis: The Rotterdam Study
Stroke, September 1, 2001; 32(9): 1947 - 1952.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. Steed, R. Kong, J. Stygall, J. Acharya, M. Bolla, M. J.G. Harrison, S. E. Humphries, and S. P. Newman
The role of apolipoprotein E in cognitive decline after cardiac operation
Ann. Thorac. Surg., March 1, 2001; 71(3): 823 - 826.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. D. Bigler, C. M. Lowry, C. V. Anderson, S. C. Johnson, J. Terry, and M. Steed
Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype
AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1857 - 1868.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. O. McCarron, K. W. Muir, J. A. R. Nicoll, J. Stewart, Y. Currie, K. Brown, and I. Bone
Prospective Study of Apolipoprotein E Genotype and Functional Outcome Following Ischemic Stroke
Arch Neurol, October 1, 2000; 57(10): 1480 - 1484.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by AAN Enterprises, Inc.