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Neurology 1999;53:1335
© 1999 American Academy of Neurology
Brief Communications

An inverse correlation of HTLV-I viral load in CSF and intrathecal synthesis of HTLV-I antibodies in TSP/HAM

M. Puccioni-Sohler, MD, PhD, M. Rios, PhD, C. Bianco, MD, S. W. Zhu, MD, C. Oliveira, MD, S. A. P. Novis, MD, PhD and M. S. Pombo-de-Oliveira, MD, PhD

From the Division of Neurology (Drs. Puccioni-Sohler and Novis), Universidade Federal do Rio de Janeiro (HUCFF/UFRJ); CSF Laboratory of Rio de Janeiro Neurolife (Drs. Puccioni-Sohler and Oliveira); Instituto Nacional do Cancer (Dr. Pombo-de-Oliveira), Rio de Janeiro, Brazil; and New York Blood Center (Drs. Rios, Bianco, and Zhu), New York.

Address correspondence and reprint requests to Dr. Puccioni-Sohler, Division of Neurology, Federal University of Rio de Janeiro, Rua 19 de Fevereiro 185/705, 22280 030, Rio de Janeiro, Brazil.

The authors measured human T-cell lymphotrophic virus type I (HTLV-I) proviral load and intrathecal synthesis of antibodies to HTLV-I in CSF of 13 Brazilian patients with tropical spastic paraparesis/HTLV-I–associated myelopathy (HAM). The authors also measured HTLV-I proviral load in peripheral blood mononuclear cells of five of these patients and found that it was 10- to 100-fold higher than that in CSF cells. The combination of HTLV-I proviral load and intrathecal synthesis of antibodies to HTLV-I appears to be a useful marker of disease progression. Patients with high viral load and no intrathecal synthesis of antibodies to HTLV-I had more rapidly progressing, serious clinical disease.

Key words: HTLV-I—CSF—Viral load—Tropical spastic paraparesis/HTLV-I–associated myelopathy.




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