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Neurology 1999;53:1345
© 1999 American Academy of Neurology


Brief Communications

Corpus callosum measurements in girls with Tourette syndrome

S. H. Mostofsky, MD, J. Wendlandt, BS, L. Cutting, PhD, M. B. Denckla, MD and H. S. Singer, MD

From the Kennedy Krieger Institute (Drs. Mostofsky, Cutting, and Denckla), the Department of Neurology (Drs. Mostofsky, Denckla, and Singer, and J. Wendlandt), the Department of Psychiatry (Dr. Denckla), and the Department of Pediatrics (Drs. Denckla and Singer), Johns Hopkins University School of Medicine, Baltimore, MD.

Address correspondence and reprint requests to Dr. Stewart H. Mostofsky, Behavioral Neurogenetics and Neuroimaging Research Center, Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205.

The objective of this study was to examine whether abnormalities in corpus callosum morphology, previously reported in boys with Tourette syndrome (TS), were also present in girls with this disorder. Among the three groups of girls—TS, TS and attention deficit hyperactivity disorder, and controls—there were no significant differences in the size of the corpus callosum or any of five individual subregions. The findings suggest that abnormalities in corpus callosum morphology in TS are a gender-related phenomenon.

Key words: Tourette syndrome—Corpus callosum—MRI.




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