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From the Department of Neurology, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia.
Address correspondence and reprint requests to Dr. Amy Brodtmann, Department of Neurology, The Royal Melbourne Hospital, Grattan Street, Parkville 3052, Australia.
Seven untreated patients with idiopathic generalized epilepsy were studied with recovery curve analysis using transcranial magnetic stimulation and compared with 16 controls. Patients had a shorter period of inhibition of the test response following a conditioning stimulus and demonstrated a period of increased facilitation of the test response at interstimulus intervals of 200 to 300 msec, which was similar to the mean interdischarge interval of spike-wave activity on EEG. This provides further evidence of cortical hyperexcitability in idiopathic generalized epilepsy.
Key words: Idiopathic generalized epilepsy—Cortical excitability—Recovery curve analysis.
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