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Neurology 1999;53:1350
© 1999 American Academy of Neurology
Brief Communications

HLA-DQ1 associated with reflex sympathetic dystrophy

M. A. Kemler, MD*, A. C. van de Vusse, MD*, E. M. van den Berg-Loonen, PhD, G. A. M. Barendse, MD, M. van Kleef, MD, PhD and W. E. J. Weber, MD, PhD

From the Pain Management and Research Centre, Department of Anesthesiology (Drs. van de Vusse, Barendse, van Kleef, and Weber), Department of Surgery (Dr. Kemler), and Tissue Typing Laboratory (Dr. van den Berg-Loonen), Maastricht University Hospital, Maastricht, the Netherlands.

Address correspondence and reprint requests to Dr. Wilhelm E.J. Weber, Department of Anesthesiology, Maastricht University Hospital, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands; e-mail: wwe{at}sane.azm.nl

Reflex sympathetic dystrophy (RSD) is a relatively common disabling disorder of unknown pathophysiology. From a cohort of 52 patients, carefully selected to fulfill the recently formulated diagnostic criteria for RSD, venous blood samples were taken for typing of class I and II major histocompatibility antigens. The frequency of HLA-DQ1 was found to be significantly increased compared with control frequencies. The association provides an indication for an organic basis of RSD.

Key words: HLA–DQ1—Reflex sympathetic dystropy.




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