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Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis

From the Departments of Immunology (Dr. Fernandez-Arquero, A. Rubio, P. Vigil, L. Conejero, and Drs. Figueredo and de la Concha) and Neurology (Drs. Arroyo and Martin), San Carlos University Hospital, Madrid, Spain.

Address correspondence and reprint requests to Dr. Emilio Gómez de la Concha, Immunology Department, Hospital Universitario San Carlos, 28040 Madrid, Spain; e-mail: egomezdela{at}hcsc.insalud.es

The associations of three promoter polymorphisms in the tumor necrosis factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and theTNFA-376 polymorphism. This association was independent of the human leukocyte antigen (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the TNFA-376A allele more than additively increased susceptibility to MS.

Key words: MS—Tumor necrosis factor—HLA class II—Polymorphism—Gene association.

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