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From the Department of Neurology (Drs. Schneider, Michel, and Nau), University of Göttingen, Germany; and the Departments of Medical Microbiology, University of Düsseldorf (Dr. Zysk), Germany, and University of Bern (Dr. Dubuis), Switzerland.
Address correspondence and reprint requests to Dr. Roland Nau, Department of Neurology, University Hospital, Robert-Koch-Straße 40, D-37075 Göttingen, Germany.
Lipoteichoic and teichoic acids are components of the cell wall of Streptococcus pneumoniae. A recently developed enzyme immunoassay was used in patients with pneumococcal meningitis to investigate lipoteichoic and teichoic acid concentrations in CSF at the first lumbar puncture in relation to the clinical outcome determined by the Glasgow Outcome Scale. Lipoteichoic and teichoic acid concentrations in CSF were significantly associated with neurologic sequelae and mortality in S. pneumoniae meningitis.
Key words: Lipoteichoic acid—Teichoic acid—Streptococcus pneumoniae—Meningitis—CSF.
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