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Neurology 1999;53:1862
© 1999 American Academy of Neurology
Brief Communications

Amantadine-induced peripheral neuropathy

Lisa M. Shulman, MD, Alireza Minagar, MD, Khema Sharma, MD and William J. Weiner, MD

From the Department of Neurology, University of Miami School of Medicine, Miami, FL.

Address correspondence and reprint requests to Dr. Lisa M. Shulman, Department of Neurology, University of Miami School of Medicine, 1501 N.W. 9 Avenue, Miami, FL 33136.

We report a 48-year-old woman with a 17-year history of PD who developed a peripheral sensory-motor neuropathy secondary to chronic administration (8 years) of amantadine. Discontinuation of amantadine resulted in resolution of trophic skin ulcers, paresthesias, and distal weakness. Amantadine may be hazardous to patients with severe and chronic livedo reticularis.

Key words: Amantadine—Peripheral neuropathy—PD.




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