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Neurology 1999;53:1882
© 1999 American Academy of Neurology
Brief Communications

Transient and falsely lateralizing flumazenil-PET asymmetries in temporal lobe epilepsy

P. Ryvlin, MD, PhD, S. Bouvard, PhD, D. Le Bars, PhD and F. Mauguière, MD, PhD

From the Department of Functional Neurology and Epileptology (Drs. Ryvlin, Bouvard, and Mauguière); and CERMEP, Neurological Hospital (Drs. Ryvlin, Bouvard, Le Bars, and Mauguière), Lyon, France.

Address correspondence and reprint requests to Dr. P. Ryvlin, CERMEP, Hopital Neurologique, 59 Bd Pinel, Lyon, 69003, France.

We have observed a falsely lateralizing mesial temporal [11C]-flumazenil binding asymmetry in three patients who had temporal lobe epilepsy (TLE) with normal hippocampal volumes. This abnormality was not detected 3 months later in two of the patients who underwent a second PET study. We conclude that transient and falsely lateralizing changes of flumazenil binding might occur in patients with TLE and no hippocampal sclerosis.

Key words: Epilepsy—PET—Flumazenil—Benzodiazepine receptors.




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