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No evidence of hypoxic tissue on ¹⁸F-fluoromisonidazole PET after intracerebral hemorrhage

From the National Stroke Research Institute (Drs. Hirano, Read, Abbott, Bladin, and Donnan), Center for Positron Emission Tomography (Drs. Abbott, Sachinidis, Tochon-Danguy, Egan, Scott, and McKay), and Ludwig Institute for Cancer Research (Dr. Scott), Austin and Repatriation Medical Center; and Department of Medicine (Drs. Read and Donnan), University of Melbourne, Australia.

Address correspondence and reprint rerquests to Dr. G.A. Donnan, National Stroke Research Institute, Level 1, Boronia Center, Austin and Repatriation Medical Center, Repatriation Campus, Bell Street, West Heidelberg, VIC 3081, Australia.

We studied six patients after intracerebral hemorrhage (ICH) and eight controls using positron emission tomography (PET) with to determine whether a zone of tissue hypoxia, possibly representing "penumbral" tissue, exists surrounding an intracerebral hemorrhage. None of the stroke patients, studied 24 to 43 hours after symptom onset, nor any of the controls exhibited areas of tissue hypoxia on ¹⁸F-fluoromisonidazole PET images. These findings may have implications for the treatment of intracerebral hemorrhage with neuroprotective strategies.

Key words: Cerebral hemorrhage—Positron emission tomography—Nitroimidazoles.

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