| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Radiology (Drs. Allison and Figueroa and J.C. Wright) and Neurology (Drs. Meador and Loring), Medical College of Georgia, Augusta, GA.
Address correspondence and reprint requests to Dr. Jerry D. Allison, Department of Radiology, Medical College of Georgia, Augusta, GA 30912.
OBJECTIVE: To examine interhemispheric interactions of motor processes by using functional MRI (fMRI).
BACKGROUND: Despite evidence of interhemispheric inhibition from animal, clinical, and transcranial magnetic stimulation (TMS) studies, fMRI has not been used to explore activation and deactivation during unilateral motor tasks. fMRI changes associated with motor activity have traditionally been described by comparing cerebral activation during motor tasks relative to a "resting state." In addition to this standard comparison, we examined fMRI changes in the resting state relative to a motor task.
METHODS: Thirteen healthy volunteers performed self-paced sequential finger/thumb tapping for each hand. During fMRI data acquisition, four epochs were obtained; each comprised of 30 seconds of rest, 30 seconds of right hand activity, and 30 seconds of left hand activity. Resultant echoplanar images were spatially normalized and spatially and temporally smoothed.
RESULTS: As expected, hand movements produced activation in the contralateral sensorimotor cortex and adjacent subcortical regions and, when present, the ipsilateral cerebellum. However, hand movement also produced a significant deactivation (i.e., decreased blood flow) in the ipsilateral sensorimotor cortex and subcortical regions, and when present, the contralateral cerebellum. Conjunction analysis demonstrated regions that are activated by one hand and deactivated by the contralateral hand.
CONCLUSION: Unilateral hand movements are associated with contralateral cerebral activation and ipsilateral cerebral deactivation, which we hypothesize result from transcallosal inhibition.
Key words: Functional MRI—Motor—Physiology—Inhibition
This article has been cited by other articles:
|
|
 |
|
  U. Schridde, M. Khubchandani, J. E. Motelow, B. G. Sanganahalli, F. Hyder, and H. Blumenfeld Negative BOLD with Large Increases in Neuronal Activity Cereb Cortex, August 1, 2008; 18(8): 1814 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Huber, S. Maatta, S. K. Esser, S. Sarasso, F. Ferrarelli, A. Watson, F. Ferreri, M. J. Peterson, and G. Tononi Measures of Cortical Plasticity after Transcranial Paired Associative Stimulation Predict Changes in Electroencephalogram Slow-Wave Activity during Subsequent Sleep J. Neurosci., July 30, 2008; 28(31): 7911 - 7918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. de Celis Alonso, A. S. Lowe, J. P. Dear, K. C. Lee, S. C. R. Williams, and G. T. Finnerty Sensory Inputs from Whisking Movements Modify Cortical Whisker Maps Visualized with Functional Magnetic Resonance Imaging Cereb Cortex, June 1, 2008; 18(6): 1314 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Hayashi, D. N. Saito, Y. Aramaki, T. Asai, Y. Fujibayashi, and N. Sadato Hemispheric Asymmetry of Frequency-Dependent Suppression in the Ipsilateral Primary Motor Cortex During Finger Movement: A Functional Magnetic Resonance Imaging Study Cereb Cortex, April 15, 2008; (2008) bhn053v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Soteropoulos and S. N. Baker Different Contributions of the Corpus Callosum and Cerebellum to Motor Coordination in Monkey J Neurophysiol, November 1, 2007; 98(5): 2962 - 2973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L Wolf Revisiting Constraint-Induced Movement Therapy: Are We Too Smitten With the Mitten? Is All Nonuse "Learned"? and Other Quandaries Physical Therapy, September 1, 2007; 87(9): 1212 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Arthurs, T Donovan, D. Spiegelhalter, J. Pickard, and S. Boniface Intracortically Distributed Neurovascular Coupling Relationships within and between Human Somatosensory Cortices Cereb Cortex, March 1, 2007; 17(3): 661 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hlushchuk and R. Hari Transient Suppression of Ipsilateral Primary Somatosensory Cortex during Tactile Finger Stimulation J. Neurosci., May 24, 2006; 26(21): 5819 - 5824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Ward, M. M. Brown, A. J. Thompson, and R. S. J. Frackowiak Neural correlates of outcome after stroke: a cross-sectional fMRI study Brain, June 1, 2003; 126(6): 1430 - 1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Ward and R. S. J. Frackowiak Age-related changes in the neural correlates of motor performance Brain, April 1, 2003; 126(4): 873 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Oktem, B. Diren, E. Karaagaoglu, and B. Anlar Functional Magnetic Resonance Imaging in Children With Asperger's Syndrome J Child Neurol, April 1, 2001; 16(4): 253 - 256. [Abstract] [PDF]
|
|
|
|
|
|
S. Bense, T. Stephan, T. A. Yousry, T. Brandt, and M. Dieterich Multisensory Cortical Signal Increases and Decreases During Vestibular Galvanic Stimulation (fMRI) J Neurophysiol, February 1, 2001; 85(2): 886 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Reddy, P. M. Matthews, M. Lassonde, J. D. Allison, K. J. Meador, D. W. Loring, R. E. Figueroa, and J. C. Wright Functional MRI cerebral activation and deactivation during finger movement Neurology, October 24, 2000; 55(8): 1244 - 1244. [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Prendergast and A. P. Moran Review: Lipopolysaccharides in the development of the Guillain-Barre syndrome and Miller Fisher syndrome forms of acute inflammatory peripheral neuropathies Innate Immunity, October 1, 2000; 6(5): 341 - 359. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
