Neurology 2000;54:240
© 2000 American Academy of Neurology
Brief Communications
Serum cholesterol, APOE genotype, and the risk of Alzheimer’s disease: A population-based study of African Americans
R. M. Evans, MD,
C. L. Emsley, MS,
S. Gao, PhD,
A. Sahota, PhD,
K. S. Hall, PhD,
M. R. Farlow, MD and
H. Hendrie, MB, ChB
From the Departments of Neurology (Drs. Evans and Farlow), Medicine (Dr. Gao and C.L. Emsley), and Psychiatry (Drs. Hall and Hendrie), Indiana University School of Medicine, Indiannapolis, IN; and the Department of Genetics (Dr. Shota), Rutgers University, New Brunswick, NJ.
Address correspondence and reprint requests to Dr. Hugh C. Hendrie, Professor and Chairman, Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Room 298, Indianapolis, IN 46202-5111.
A significant interaction among total serum cholesterol (TC), APOE genotype, and AD risk was found in a population-based study of elderly African Americans. Increasing TC was associated with increased AD risk in the group with no  4 alleles, whereas TC was not associated with increased AD risk in the group with one or more 4 alleles. Further study of the relationship between cholesterol and APOE genotype is needed to confirm this association, but the results suggest that cholesterol may be a potentially modifiable environmental risk factor for AD.
Key words: Cholesterol—APOE genotype—AD—African American
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