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Neurology 2000;54:247
© 2000 American Academy of Neurology
Brief Communications

Apomorphine can sustain the long-duration response to L-DOPA in fluctuating PD

John G. Nutt, MD and Julie H. Carter, RN, MN, ANP

From the Departments of Neurology and Physiology & Pharmacology (Dr. Nutt), School of Medicine; and the Department of Neurology (J.H. Carter), School of Medicine and School of Nursing, Oregon Health Sciences University, Portland, OR.

Address correspondence and reprint requests to Dr. John G. Nutt, Department of Neurology, L-226, Portland, OR 97201-3098; e-mail: nuttj{at}ohsu.edu

The authors investigated the ability of daytime infusions of apomorphine, a D-1 and D-2 dopamine agonist, to sustain the long-duration response (LDR) in seven subjects with fluctuating PD in whom L-DOPA was discontinued for 3 days. Apomorphine maintained the LDR to the extent that it kept the subjects "on" during the day. This observation suggests that the LDR can be a postsynaptic effect, independent of dopamine storage.

Key words: Long-duration response—Short-duration response—Levodopa—Apomorphine




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