| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Neurology (Drs. Van den Berg-Vos, Van den Berg, and Wokke), Clinical Neurophysiology (Dr. Franssen), Radiology (Dr. Witkamp), and Pathology (Dr. Jansen), Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht; the Department of Neurology (Dr. Vermeulen), Academic Medical Center, Amsterdam; the Department of Neurology (Dr. Kerkhoff), University Hospital Maastricht; and the Department of Radiology (Dr. van Es), St. Antonius Hospital, Nieuwegein, the Netherlands.
Address correspondence and reprint requests to Dr. L.H. Van den Berg, Department of Neurology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands; e-mail: l.h.vandenberg{at}neuro.azu.nl
BACKGROUND: Several patients have been reported with an asymmetric sensory or sensorimotor demyelinating neuropathy not fulfilling the diagnostic criteria for chronic inflammatory demyelinating polyneuropathy or multifocal motor neuropathy.
OBJECTIVE: To present the clinical, electrophysiologic, radiologic, and pathologic features of six patients with an asymmetric sensory or sensorimotor demyelinating neuropathy.
RESULTS: All six patients were initially affected in only one limb; in four patients the neuropathy progressed to other limbs in an asymmetric fashion during several years. On electrophysiologic examination, evidence of multifocal demyelination and conduction block in motor and sensory nerves was found in all patients. MRI of the brachial plexus revealed swollen nerves and an increased signal intensity on T2-weighted imaging in four patients. A biopsy sample taken from the brachial plexus of one patient revealed evidence of inflammation. All patients showed a beneficial response to IV immunoglobulin treatment. Thirty-four similar patients have been reported previously, many of whom were initially diagnosed as having various other (nontreatable) diseases.
CONCLUSIONS: The authors propose calling this neuropathy "multifocal inflammatory demyelinating neuropathy" and considering it as a distinct clinical entity to facilitate early diagnosis of this treatable disorder.
Key words: Multifocal inflammatory demyelinating neuropathy—Chronic inflammatory demyelinating polyneuropathy—Multifocal motor neuropathy—Demyelinating neuropathy
This article has been cited by other articles:
|
|
 |
|
  M. Slee, A. Selvan, and M. Donaghy Multifocal motor neuropathy: The diagnostic spectrum and response to treatment Neurology, October 23, 2007; 69(17): 1680 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Tackenberg, J. D. Lunemann, A. Steinbrecher, E. Rothenfusser-Korber, M. Sailer, W. Bruck, S. Schock, R. Zschenderlein, F. Zipp, and N. Sommer Classifications and treatment responses in chronic immune-mediated demyelinating polyneuropathy Neurology, May 8, 2007; 68(19): 1622 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Weiss, J. C. Oakley, and G. D. Meekins Hypoglossal neuropathy in Lewis-Sumner syndrome masquerading as motor neuron disease. Neurology, July 11, 2006; 67(1): 175 - 176. [Full Text] [PDF]
|
|
|
|
|
|
S. J. Oh, C. LaGanke, R. Powers, G. I. Wolfe, R. A. Quinton, and D. K. Burns Multifocal motor sensory demyelinating neuropathy: Inflammatory demyelinating polyradiculoneuropathy Neurology, November 22, 2005; 65(10): 1639 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Odaka, M Tatsumoto, K Susuki, K Hirata, and N Yuki Intractable chronic inflammatory demyelinating polyneuropathy treated successfully with ciclosporin J. Neurol. Neurosurg. Psychiatry, August 1, 2005; 76(8): 1115 - 1120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Viala, L. Renie, T. Maisonobe, A. Behin, J. Neil, J. M. Leger, and P. Bouche Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome Brain, September 1, 2004; 127(9): 2010 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Sander and N. Latov Research criteria for defining patients with CIDP Neurology, April 22, 2003; 60(90083): S8 - 15. [Abstract] [Full Text]
|
|
|
|
|
|
J. T. H. Van Asseldonk, L. H. Van den Berg, R. M. Van den Berg-Vos, G. H. Wieneke, J. H. J. Wokke, and H. Franssen Demyelination and axonal loss in multifocal motor neuropathy: distribution and relation to weakness Brain, January 1, 2003; 126(1): 186 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alaedini, H. W. Sander, A. P. Hays, and N. Latov Antiganglioside Antibodies in Multifocal Acquired Sensory and Motor Neuropathy Arch Neurol, January 1, 2003; 60(1): 42 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Koski Therapy of CIDP and related immune-mediated neuropathies Neurology, December 24, 2002; 59(90126): S22 - 27. [Abstract] [Full Text]
|
|
|
|
|
|
M. P. Collins, J. R. Mendell, M. I. Periquet, Z. Sahenk, A. A. Amato, G. S. Gronseth, R. J. Barohn, C. E. Jackson, and J. T. Kissel Superficial peroneal nerve/peroneus brevis muscle biopsy in vasculitic neuropathy Neurology, September 12, 2000; 55(5): 636 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Oh, L. H. Van den Berg, R. M. Van den Berg-Vos, H. Franssen, and J. H. J. Wokke Multifocal inflammatory demyelinating neuropathy: A distinct clinical entity? Neurology, September 12, 2000; 55(5): 735 - 742. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
