HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tarkowski, E. Articles by Blennow, K. Search for Related Content PubMed PubMed Citation Articles by Tarkowski, E. Articles by Blennow, K.

TNF gene polymorphism and its relation to intracerebral production of TNF and TNFß in AD

From the Departments of Rheumatology (Dr. Tarkowski), Clinical Neurosciences (Sections of Neurology [Dr. Tarkowski] and Neurochemistry [Drs. Davidsson and Blennow]), and Clinical Chemistry (Dr. Ricksten), University of Göteborg; the Department of Community Medicine and Neuropsychiatric Clinic (Drs. Liljeroth, Nilsson, and Minthon), University of Lund/Malmö; and the Medical Research Council (Dr. Blennow), Stockholm, Sweden.

Address correspondence and reprint requests to Dr. Elisabeth Tarkowski, Department of Rheumatology, Guldhedsgatan 10, S-413 46 Göteborg, Sweden.

OBJECTIVE: To analyze the extent of tumor necrosis factor- (TNF) and TNFß gene polymorphism in patients with AD and to relate it to intrathecal levels of these cytokines.

METHODS: Analyses of TNF and TNFß gene polymorphism were performed using PCR in 52 patients with AD and in 25 control subjects, and the levels of corresponding cytokines were analyzed using ELISA.

RESULTS: Patients with AD displayed significantly higher intrathecal levels of TNF, but not TNFß, compared with the control subjects. The levels of these cytokines did not differ significantly in patients displaying different alleles of the TNF gene.

CONCLUSIONS: Results indicate that increased intrathecal production of TNF in AD is preferentially controlled by environmental stimuli rather than genetic makeup.

Key words: AD—Tumor necrosis factor-—Tumor necrosis factor-ß—Gene polymorphism.

This article has been cited by other articles:

				T. K. Khan and D. L. Alkon An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin PNAS, August 29, 2006; 103(35): 13203 - 13207. [Abstract] [Full Text] [PDF]

				E Tarkowski, N Andreasen, A Tarkowski, and K Blennow Intrathecal inflammation precedes development of Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, September 1, 2003; 74(9): 1200 - 1205. [Abstract] [Full Text] [PDF]