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Neurology 2000;54:2150-2153
© 2000 American Academy of Neurology
Brief Communications

Hippocampal sulcal cavities on MRI: Relationship to age and apolipoprotein E genotype

D. P. Barboriak, MD, P. M. Doraiswamy, MD, K. R. R. Krishnan, MD, S. Vidyarthi, BS, J. Sylvester, BS and H. C. Charles, PhD

From the Departments of Radiology (Drs. Barboriak and Charles), Medicine (Dr. Doraiswamy), and Psychiatry (Drs. Doraiswamy and Krishnan, and S. Vidyarthi and J. Sylvester), and the Center for the Study of Aging and Human Development (Drs. Krishnan and Doraiswamy), Duke University Medical Center, Durham, NC.

Address correspondence and reprint requests to Dr. Daniel P. Barboriak, Neuroradiology Section, Department of Radiology, Box 3808, Duke University Medical Center, Durham, NC 27710; e-mail: barbo013{at}mc.duke.edu

Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased with age, and were higher in subjects carrying the APOE {epsilon}4 or {epsilon}2 alleles than in subjects with the {epsilon}3/3 genotype. Age-related morphologic changes in the hippocampus may be mediated by the APOE genotype.

Key words: Hippocampal sulcal cavities—MRI—APOE.




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