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Neurology 2000;54:2163-2165
© 2000 American Academy of Neurology
Brief Communications

Status epilepticus with neuron-reactive serum antibodies: Response to plasma exchange

M. Lousa, MD, PhD, S. Sanchez–Alonso, MD, R. Rodriguez–Diaz, MD and J. Dalmau, MD, PhD

From the Servicio de Neurología (Dr. Lousa), Unidad de Cuidados Intensivos (Drs. Sanchez-Alonso and Rodriguez-Diaz), Hospital Ramón y Cajal, Madrid, Spain; and the Department of Neurology (Dr. Dalmau), Memorial Sloan–Kettering Cancer Center, Cornell University Medical Center, New York, NY.

Address correspondence and reprint requests to Dr. Manuel Lousa, Servicio de Neurologia, Hospital Ramón y Cajal, Carrt. De Colmenar Km 9, 28034 Madrid, Spain.

The authors report a patient with partial and secondarily generalized status epilepticus who required 70 days of general anesthesia for seizure control. Although antiepileptic medications failed to control the seizures, they resolved with plasma exchange. The patient’s serum reacted with rat cerebral cortex, hippocampus, and cerebellum, but not with cells expressing the glutamate receptor GluR3. These findings suggest an immune response against neuronal antigens other than GluR3.

Key words: Status epilepticus—Rasmussen’s encephalitis—Plasma exchange—Glutamate receptor—Antibodies to GluR3.




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