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Neurology 2000;54:2173-2176
© 2000 American Academy of Neurology
Brief Communications

Autosomal dominant partial epilepsy with auditory features: Defining the phenotype

Melodie R. Winawer, MD, Ruth Ottman, PhD, W. Allen Hauser, MD and Timothy A. Pedley, MD

From the G.H. Sergievsky Center and Mailman School of Public Health (Epidemiology Division) (Drs. Winawer, Ottman, and Hauser), and the Department of Neurology (Drs. Winawer, Hauser, and Pedley), Columbia University; Epidemiology of Brain Disorders Department (Dr. Ottman), New York State Psychiatric Institute, New York, NY.

Address correspondence and reprint requests to Dr. Ruth Ottman, G.H. Sergievsky Center, Columbia University, 630 W. 168th Street, New York, NY 10032; e-mail: ro6{at}columbia.edu

The authors previously reported linkage to chromosome 10q22-24 for autosomal dominant partial epilepsy with auditory features. This study describes seizure semiology in the original linkage family in further detail. Auditory hallucinations were most common, but other sensory symptoms (visual, olfactory, vertiginous, and cephalic) were also reported. Autonomic, psychic, and motor symptoms were less common. The clinical semiology points to a lateral temporal seizure origin. Auditory hallucinations, the most striking clinical feature, are useful for identifying new families with this synome.

Key words: Genetics—Epidemiology—Epilepsy—Auditory—Partial seizures.




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