| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Psychiatry (Dr. Tariot), University of Rochester Medical Center, NY; Department of Psychology (Dr. Solomon), Williams College, MA, and the Memory Clinic, Southwestern Vermont Medical Center, Bennington, VT; Department of Neurology (Dr. Morris), Washington University School of Medicine, St. Louis, MO; the Janssen Research Foundation (Drs. Kershaw and Ding), Titusville, NJ; and the Janssen Research Foundation (Dr. Lilienfeld), Beerse, Belgium.
Address correspondence and reprint requests to Dr. Pierre N. Tariot, Department of Psychiatry, Monroe Community Hospital, 435 East Henrietta Road, Rochester, NY 14620.
OBJECTIVE: To investigate the efficacy and tolerability of galantamine, using a slow dose escalation schedule of up to 8 weeks, in 978 patients with mild to moderate AD.
METHODS: A 5-month multicenter, placebo-controlled, double-blind trial. Following a 4-week placebo run-in, patients were randomized to one of four treatment arms: placebo or galantamine escalated to final maintenance doses of 8, 16, or 24 mg/day. Outcome measures included the cognitive subscale of the AD Assessment Scale (ADAS-cog), the Clinician’s Interview-Based Impression of Change plus Caregiver Input (CIBIC-plus), the AD Cooperative Study Activities of Daily Living inventory, and the Neuropsychiatric Inventory. Standard safety evaluations and adverse event monitoring were carried out.
RESULTS: After 5 months, the galantamine–placebo differences on ADAS-cog were 3.3 points for the 16 mg/day group and 3.6 points for the 24 mg/day group (p < 0.001 versus placebo, both doses). Compared with placebo, the galantamine 16- and 24-mg/day groups also had a significantly better outcome on CIBIC-plus, activities of daily living, and behavioral symptoms. Treatment discontinuations due to adverse events were low in all galantamine groups (6 to 10%) and comparable with the discontinuation rate in the placebo group (7%). The incidence of adverse events in the galantamine groups, notably gastrointestinal symptoms, was low and most adverse events were mild.
CONCLUSIONS: Galantamine 16 and 24 mg/day significantly benefits the cognitive, functional, and behavioral symptoms of AD as compared with placebo. Slow dose escalation appears to enhance the tolerability of galantamine, minimizing the incidence and severity of adverse events.
Key words: AD—Galantamine—Allosteric modulation—Nicotinic receptors—Acetylcholinesterase inhibition—Randomized controlled trial—Efficacy—Dose escalation—Tolerability.
This article has been cited by other articles:
|
|
 |
|
  D. A. Smith Treatment of Alzheimer's disease in the long-term-care setting Am. J. Health Syst. Pharm., May 15, 2009; 66(10): 899 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Doody, S. H. Ferris, S. Salloway, Y. Sun, R. Goldman, W. E. Watkins, Y. Xu, and A. K. Murthy Donepezil treatment of patients with MCI: A 48-week randomized, placebo-controlled trial Neurology, May 5, 2009; 72(18): 1555 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.R. Petrella, S.E. Prince, S. Krishnan, H. Husn, L. Kelley, and P.M. Doraiswamy Effects of Donepezil on Cortical Activation in Mild Cognitive Impairment: A Pilot Double-Blind Placebo-Controlled Trial Using Functional MR Imaging AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 411 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Smith, E. Kramer, Y. Ma, C. R. Hermann, V. Dhawan, T. Chaly, and D. Eidelberg Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease Brain, February 1, 2009; 132(2): 392 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tangwongchai, N. Thavichachart, V. Senanarong, N. Poungvarin, K. Phanthumchinda, R. Praditsuwan, S. Nidhinandana, and S. Chankrachang Galantamine for the Treatment of BPSD in Thai Patients With Possible Alzheimer's Disease With or Without Cerebrovascular Disease American Journal of Alzheimer's Disease and Other Dementias, January 1, 2009; 23(6): 593 - 601. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Raina, P. L. Santaguida, and C. Patterson The Importance of Measuring Executive Function When Studying the Effects of Cognition-Enhancing Agents Ann Intern Med, September 2, 2008; 149(5): 359 - 360. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Erkinjuntti, S. Gauthier, R. Bullock, A. Kurz, G. Hammond, S. Schwalen, Y. Zhu, and R. Brashear Galantamine treatment in Alzheimer's disease with cerebrovascular disease: responder analyses from a randomized, controlled trial (GAL-INT-6) J Psychopharmacol, September 1, 2008; 22(7): 761 - 768. [Abstract] [PDF]
|
|
|
|
|
|
B. Winblad, S. Gauthier, L. Scinto, H. Feldman, G. K. Wilcock, L. Truyen, A. J. Mayorga, D. Wang, H. R. Brashear, J. S. Nye, et al. Safety and efficacy of galantamine in subjects with mild cognitive impairment Neurology, May 27, 2008; 70(22): 2024 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Saddichha and V. Pandey Alzheimer's and Non-Alzheimer's Dementia: A Critical Review of Pharmacological and Nonpharmacological Strategies American Journal of Alzheimer's Disease and Other Dementias, May 1, 2008; 23(2): 150 - 161. [Abstract] [PDF]
|
|
|
|
|
|
A. Qaseem, V. Snow, J. T. Cross Jr., M. A. Forciea, R. Hopkins Jr., P. Shekelle, A. Adelman, D. Mehr, K. Schellhase, D. Campos-Outcalt, et al. Current Pharmacologic Treatment of Dementia: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians Ann Intern Med, March 4, 2008; 148(5): 370 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Raina, P. Santaguida, A. Ismaila, C. Patterson, D. Cowan, M. Levine, L. Booker, and M. Oremus Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline Ann Intern Med, March 4, 2008; 148(5): 379 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Rowland, J. Rigby, A. C. Harper, and R. Rowland Cardiovascular monitoring with acetylcholinesterase inhibitors: a clinical protocol Adv. Psychiatr. Treat., May 1, 2007; 13(3): 178 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Chappell, C. Gonzales, J. Williams, M. M. Witte, R. C. Mohs, and R. Sperling AMPA potentiator treatment of cognitive deficits in Alzheimer disease Neurology, March 27, 2007; 68(13): 1008 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rozzini, B. V. Chilovi, E. Bertoletti, M. Conti, I. Delrio, M. Trabucchi, and A. Padovani Cognitive and Psychopathologic Response to Rivastigmine in Dementia With Lewy Bodies Compared to Alzheimer's Disease: A Case Control Study American Journal of Alzheimer's Disease and Other Dementias, February 1, 2007; 22(1): 42 - 47. [Abstract] [PDF]
|
|
|
|
 |
|
 A. T. Blaszczyk and M. Mathys Treatment of Cognitive Decline and Psychiatric Disturbances Associated With Alzheimer's Dementia Journal of Pharmacy Practice, February 1, 2007; 20(1): 13 - 28. [Abstract] [PDF]
|
|
|
|
 |
|
 D Aarsland, K Bronnick, U Ehrt, P P De Deyn, S Tekin, M Emre, and J L Cummings Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress J. Neurol. Neurosurg. Psychiatry, January 1, 2007; 78(1): 36 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Burns and J. O'Brien Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology J Psychopharmacol, November 1, 2006; 20(6): 732 - 755. [Abstract] [PDF]
|
|
|
|
|
|
H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang Therapeutic approaches to Alzheimer's disease Brain, November 1, 2006; 129(11): 2840 - 2855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Farlow Use of Antidementia Agents in Vascular Dementia: Beyond Alzheimer Disease Mayo Clin. Proc., October 1, 2006; 81(10): 1350 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Cummings, E. Schneider, P. N. Tariot, S. M. Graham, and for the Memantine MEM-MD-02 Study Group Behavioral effects of memantine in Alzheimer disease patients receiving donepezil treatment. Neurology, July 11, 2006; 67(1): 57 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lopez-Pousa, J. G. Olmo, J. V. Franch, A. T. Estrada, O. S. Cors, I. P. Nierga, and E. Gelada-Batlle Comparative analysis of mortality in patients with Alzheimer's disease treated with donepezil or galantamine. Age Ageing, July 1, 2006; 35(4): 365 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Scharre Galantamine With Adjunctive Memantine: Combined Effects on Brain Nicotinic Acetylcholine Receptors and N-methyl-D-aspartate Receptors May Improve Alzheimer's Disease Symptomatology J. Clin. Pharmacol., July 1, 2006; 46(suppl_1): 6S - 7S. [Full Text] [PDF]
|
|
|
|
|
|
G. T. Grossberg, K. R. Edwards, and Q. Zhao Rationale for Combination Therapy With Galantamine and Memantine in Alzheimer's Disease J. Clin. Pharmacol., July 1, 2006; 46(suppl_1): 17S - 26S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gillette-Guyonnet, S. Andrieu, F. Cortes, F. Nourhashemi, C. Cantet, P.-J. Ousset, E. Reynish, H. Grandjean, and B. Vellas Outcome of Alzheimer's disease: potential impact of cholinesterase inhibitors. J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2006; 61(5): 516 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Unger, M. M. Svedberg, W.-F. Yu, M. M. Hedberg, and A. Nordberg Effect of Subchronic Treatment of Memantine, Galantamine, and Nicotine in the Brain of Tg2576 (APPswe) Transgenic Mice J. Pharmacol. Exp. Ther., April 1, 2006; 317(1): 30 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Aupperle Management of aggression, agitation, and psychosis in dementia: Focus on atypical antipsychotics American Journal of Alzheimer's Disease and Other Dementias, March 1, 2006; 21(2): 101 - 108. [Abstract] [PDF]
|
|
|
|
|
|
D. M. Marseille and D. H.S. Silverman Recognition and treatment of Alzheimer's disease: A case-based review American Journal of Alzheimer's Disease and Other Dementias, March 1, 2006; 21(2): 119 - 125. [Abstract] [PDF]
|
|
|
|
|
|
K. R. Peters, K. Rockwood, S. E. Black, R. Bouchard, S. Gauthier, D. Hogan, A. Kertesz, I. Loy-English, B. L. Beattie, A. D. Sadovnick, et al. Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics Neurology, February 28, 2006; 66(4): 523 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Simpson, D. Beavis, A. Leddy, S. Ball, and I. Johnson Naturalistic audit of NICE criteria for the use of cholinesterase inhibitors Psychiatr. Bull., November 1, 2005; 29(11): 410 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Xiong, K. Yu, F. Gao, Y. Yan, and Z. Zhang Power and sample size for clinical trials when efficacy is required in multiple endpoints: application to an Alzheimer's treatment trial Clinical Trials, October 1, 2005; 2(5): 387 - 393. [Abstract] [PDF]
|
|
|
|
|
|
H. H. Feldman and M. Woodward The staging and assessment of moderate to severe Alzheimer disease Neurology, September 27, 2005; 65(6_suppl_3): S10 - S17. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Cummings Neuropsychiatric and behavioral alterations and their management in moderate to severe Alzheimer disease Neurology, September 27, 2005; 65(6_suppl_3): S18 - S24. [Full Text]
|
|
|
|
|
|
M. R. Farlow The search for disease modification in moderate to severe Alzheimer disease: A critical review of current evidence Neurology, September 27, 2005; 65(6_suppl_3): S25 - S30. [Full Text]
|
|
|
|
|
|
H. Fillit Cost consequences and cost benefits of treating patients with moderate to severe Alzheimer disease Neurology, September 27, 2005; 65(6_suppl_3): S31 - S33. [Full Text]
|
|
|
|
 |
|
 H. Kaduszkiewicz, T. Zimmermann, H.-P. Beck-Bornholdt, and H. van den Bussche Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials BMJ, August 6, 2005; 331(7512): 321 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Vandenberghe and J Tournoy Cognitive aging and Alzheimer's disease Postgrad. Med. J., June 1, 2005; 81(956): 343 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N. Tariot Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia JAMA, May 11, 2005; 293(18): 2212 - 2212. [Full Text] [PDF]
|
|
|
|
|
|
K. M. Sink and K. Yaffe Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia--Reply JAMA, May 11, 2005; 293(18): 2212 - 2212. [Full Text] [PDF]
|
|
|
|
|
|
C. Yao, A. Raoufinia, M. Gold, J. S. Nye, S. Ramael, M. Padmanabhan, Y. Walschap, T. Verhaeghe, and Q. Zhao Steady-State Pharmacokinetics of Galantamine Are Not Affected by Addition of Memantine in Healthy Subjects J. Clin. Pharmacol., May 1, 2005; 45(5): 519 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Cummings Searching for Methods to Detect, Prevent, and Treat Alzheimer's Disease Am J Psychiatry, April 1, 2005; 162(4): 645 - 647. [Full Text] [PDF]
|
|
|
|
|
|
P J Connelly, N P Prentice, and K G Fowler Predicting the outcome of cholinesterase inhibitor treatment in Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, March 1, 2005; 76(3): 320 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Ellis Cholinesterase Inhibitors in the Treatment of Dementia J Am Osteopath Assoc, March 1, 2005; 105(3): 145 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Sink, K. F. Holden, and K. Yaffe Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia: A Review of the Evidence JAMA, February 2, 2005; 293(5): 596 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Moriguchi, W. Marszalec, X. Zhao, J. Z. Yeh, and T. Narahashi Mechanism of Action of Galantamine on N-Methyl-D-Aspartate Receptors in Rat Cortical Neurons J. Pharmacol. Exp. Ther., September 1, 2004; 310(3): 933 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Salloway, S. Ferris, A. Kluger, R. Goldman, T. Griesing, D. Kumar, and S. Richardson Efficacy of donepezil in mild cognitive impairment: A randomized placebo-controlled trial Neurology, August 24, 2004; 63(4): 651 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Herrmann and D. Knopman Donepezil therapy for neuropsychiatric symptoms in AD: Methods make the message Neurology, July 27, 2004; 63(2): 200 - 201. [Full Text] [PDF]
|
|
|
|
|
|
A. C. Holm Alleviation of multiple abnormalities by galantamine treatment in two patients with dementia with Lewy bodies American Journal of Alzheimer's Disease and Other Dementias, July 1, 2004; 19(4): 215 - 218. [Abstract] [PDF]
|
|
|
|
|
|
K Rockwood Size of the treatment effect on cognition of cholinesterase inhibition in Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, May 1, 2004; 75(5): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kavanagh and P. Kabathova Drug therapy for Alzheimer's disease Can. Med. Assoc. J., April 27, 2004; 170(9): 1371 - 1372. [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Cummings Use of Cholinesterase Inhibitors in Clinical Practice: Evidence-Based Recommendations Focus, April 1, 2004; 2(2): 239 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Cummings, L. Schneider, P. N. Tariot, P. R. Kershaw, and W. Yuan Reduction of Behavioral Disturbances and Caregiver Distress by Galantamine in Patients With Alzheimer's Disease Am J Psychiatry, March 1, 2004; 161(3): 532 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Raskind, E. R. Peskind, L. Truyen, P. Kershaw, and C. V. Damaraju The Cognitive Benefits of Galantamine Are Sustained for at Least 36 Months: A Long-term Extension Trial Arch Neurol, February 1, 2004; 61(2): 252 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mintzer and S. D. Targum Psychosis in Elderly Patients: Classification and Pharmacotherapy J Geriatr Psychiatry Neurol, December 1, 2003; 16(4): 199 - 206. [Abstract] [PDF]
|
|
|
|
|
|
K. L. Lanctot, N. Herrmann, K. K. Yau, L. R. Khan, B. A. Liu, M. M. LouLou, and T. R. Einarson Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis Can. Med. Assoc. J., September 16, 2003; 169(6): 557 - 564. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. H. Kawas Early Alzheimer's Disease N. Engl. J. Med., September 11, 2003; 349(11): 1056 - 1063. [Full Text] [PDF]
|
|
|
|
|
|
M. Farlow, S. Potkin, B. Koumaras, J. Veach, and D. Mirski Analysis of Outcome in Retrieved Dropout Patients in a Rivastigmine vs Placebo, 26-Week, Alzheimer Disease Trial Arch Neurol, June 1, 2003; 60(6): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Piotrovsky, A. Van Peer, N. Van Osselaer, M. Armstrong, and J. Aerssens Galantamine Population Pharmacokinetics in Patients with Alzheimer's Disease: Modeling and Simulations J. Clin. Pharmacol., May 1, 2003; 43(5): 514 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Clark and J. H.T. Karlawish Alzheimer Disease: Current Concepts and Emerging Diagnostic and Therapeutic Strategies Ann Intern Med, March 4, 2003; 138(5): 400 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Brangman Long-term cholinesterase inhibitor therapy for Alzheimer's disease: Implications for long-term care American Journal of Alzheimer's Disease and Other Dementias, March 1, 2003; 18(2): 79 - 84. [Abstract] [PDF]
|
|
|
|
|
|
N.-H. Trinh, J. Hoblyn, S. Mohanty, and K. Yaffe Efficacy of Cholinesterase Inhibitors in the Treatment of Neuropsychiatric Symptoms and Functional Impairment in Alzheimer Disease: A Meta-analysis JAMA, January 8, 2003; 289(2): 210 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bordier, S. Garrigue, S. S. Barold, N. Bressolles, S. Lanusse, and J. Clémenty Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors Europace, January 1, 2003; 5(4): 429 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.L. Murman, Q. Chen, M.C. Powell, S.B. Kuo, C.J. Bradley, and C.C. Colenda The incremental direct costs associated with behavioral symptoms in AD Neurology, December 10, 2002; 59(11): 1721 - 1729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Lyketsos, O. Lopez, B. Jones, A. L. Fitzpatrick, J. Breitner, and S. DeKosky Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment: Results From the Cardiovascular Health Study JAMA, September 25, 2002; 288(12): 1475 - 1483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Suh and F. Checler Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease Pharmacol. Rev., September 1, 2002; 54(3): 469 - 525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Fillit, R. N. Butler, A. W. O'Connell, M. S. Albert, J. E. Birren, C. W. Cotman, W. T. Greenough, P. E. Gold, A. F. Kramer, L. H. Kuller, et al. Achieving and Maintaining Cognitive Vitality With Aging Mayo Clin. Proc., July 1, 2002; 77(7): 681 - 696. [Abstract] [PDF]
|
|
|
|
|
|
J. C. Chappell and H. Cohen Frontiers in Neuropharmacotherapy Part I: Alzheimer's Disease and Epilepsy Journal of Pharmacy Practice, June 1, 2002; 15(3): 195 - 220. [Abstract] [PDF]
|
|
|
|
|
|
J. L. Cummings and G. Cole Alzheimer Disease JAMA, May 8, 2002; 287(18): 2335 - 2338. [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. J. Mannens, C. A. W. Snel, J. Hendrickx, T. Verhaeghe, L. Le Jeune, W. Bode, L. van Beijsterveldt, K. Lavrijsen, J. Leempoels, N. Van Osselaer, et al. The Metabolism and Excretion of Galantamine in Rats, Dogs, and Humans Drug Metab. Dispos., May 1, 2002; 30(5): 553 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Santos, M. Alkondon, E. F. R. Pereira, Y. Aracava, H. M. Eisenberg, A. Maelicke, and E. X. Albuquerque The Nicotinic Allosteric Potentiating Ligand Galantamine Facilitates Synaptic Transmission in the Mammalian Central Nervous System Mol. Pharmacol., May 1, 2002; 61(5): 1222 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O L Lopez, J T Becker, S Wisniewski, J Saxton, D I Kaufer, and S T DeKosky Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, March 1, 2002; 72(3): 310 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Budson, K. J. Michalska, D. M. Rentz, C. C. Joubert, K. R. Daffner, D. L. Schacter, and R. A. Sperling Use of a false recognition paradigm in an Alzheimer's disease clinical trial: A pilot study American Journal of Alzheimer's Disease and Other Dementias, March 1, 2002; 17(2): 93 - 100. [Abstract] [PDF]
|
|
|
|
|
|
S. Gauthier Advances in the pharmacotherapy of Alzheimer's disease Can. Med. Assoc. J., March 1, 2002; 166(5): 616 - 623. [Full Text] [PDF]
|
|
|
|
 |
|
 D. H.S. Silverman, S. S. Gambhir, H.-W. C. Huang, J. Schwimmer, S. Kim, G. W. Small, J. Chodosh, J. Czernin, and M. E. Phelps Evaluating Early Dementia With and Without Assessment of Regional Cerebral Metabolism by PET: A Comparison of Predicted Costs and Benefits J. Nucl. Med., February 1, 2002; 43(2): 253 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Rockwood, J Mintzer, L Truyen, T Wessel, and D Wilkinson Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial J. Neurol. Neurosurg. Psychiatry, November 1, 2001; 71(5): 589 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Neumann, S. S. Araki, A. Arcelus, A. Longo, G. Papadopoulos, K. S. Kosik, K. M. Kuntz, and A. Bhattacharjya Measuring Alzheimer's disease progression with transition probabilities: Estimates from CERAD Neurology, September 25, 2001; 57(6): 957 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Getsios, J. J. Caro, G. Caro, and K. Ishak Assessment of health economics in Alzheimer's disease (AHEAD): Galantamine treatment in Canada Neurology, September 25, 2001; 57(6): 972 - 978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Feldman, S. Gauthier, J. Hecker, B. Vellas, P. Subbiah, and E. Whalen A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease Neurology, August 28, 2001; 57(4): 613 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Mohs, R. S. Doody, J.C. Morris, J. R. Ieni, S. L. Rogers, C. A. Perdomo, and R. D. Pratt A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients Neurology, August 14, 2001; 57(3): 481 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T O'Brien and C. G Ballard Drugs for Alzheimer's disease BMJ, July 21, 2001; 323(7305): 123 - 124. [Full Text] [PDF]
|
|
|
|
|
|
J. L. Cummings, A. Nadel, D. Masterman, and P. A. Cyrus Efficacy of Metrifonate in Improving the Psychiatric and Behavioral Disturbances of Patients with Alzheimer's Disease J Geriatr Psychiatry Neurol, June 1, 2001; 14(2): 101 - 108. [Abstract] [PDF]
|
|
|
|
|
|
R. S. Doody, J.C. Stevens, C. Beck, R.M. Dubinsky, J.A. Kaye, L. Gwyther, R.C. Mohs, L.J. Thal, P.J. Whitehouse, S.T. DeKosky, et al. Practice parameter: Management of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology Neurology, May 8, 2001; 56(9): 1154 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Pearce Review: donepezil, metrifonate, rivastigmine, and Ginkgo biloba are more effective than placebo in Alzheimer's disease Evid. Based Ment. Health, February 1, 2001; 4(1): 24 - 24. [Full Text]
|
|
|
|
 |
|
 J. Pearce Review: donepezil, metrifonate, rivastigmine, and Ginkgo biloba are more effective than placebo in Alzheimer's disease Evid. Based Med., January 1, 2001; 6(1): 14 - 14. [Full Text]
|
|
|
|
|
|
G. K Wilcock, S. Lilienfeld, and E. Gaens Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial BMJ, December 9, 2000; 321(7274): 1445 - 1445. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Raskind, E. R. Peskind, T. Wessel, and W. Yuan Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension Neurology, June 27, 2000; 54(12): 2261 - 2268. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
