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Neurology 2000;54:2342-2344
© 2000 American Academy of Neurology
Brief Communications

Thalamic stimulation for the treatment of midline tremors in essential tremor patients

A. A. Obwegeser, MD, R. J. Uitti, MD, M. F. Turk, MSN, A. J. Strongosky, BA and R. E. Wharen, MD

From the Departments of Neurosurgery (Drs. Obwegeser and Wharen), and Neurology (Drs. Uitti, Turk, and Mr. Strongosky), Mayo Clinic Jacksonville, Florida; and the Department of Neurosurgery (Dr. Obwegeser), University Innsbruck, Austria.

Address correspondence and reprint requests to Dr. Robert E. Wharen, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224; e-mail: wharen{at}mayo.edu

The authors prospectively collected unblinded data from 27 consecutive patients following thalamic stimulation. A significant reduction of midline tremor was achieved after unilateral surgery, but a staged contralateral surgery had an additional effect. A subgroup analysis showed significant beneficial effects for head, voice, tongue, and face tremor. The most frequent reversible side effects were disequilibrium, dysarthria, and paresthesias. We observed more pulse generator adjustments for speech problems in the bilaterally implanted group.

Key words: Thalamic nuclei—Stimulation—Essential tremor.




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