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Neurology 2000;54:485
© 2000 American Academy of Neurology
Brief Communications

No induction of apoptosis by IFN-ß in human antigen-specific T cells

F. Zipp, MD, M. Beyer, MD, H. Gelderblom, MD, D. Wernet, MD, R. Zschenderlein, MD and M. Weller, MD

From the Department of Neurology, Division of Neuroimmunology (Drs. Zipp, Beyer, Gelderblom, and Zschenderlein), University Hospital Charité, Berlin; and the Departments of Transfusion Medicine (Dr. Wernet) and Neurology, Division of Neurooncology (Dr. Weller), University of Tübingen, Germany.

Address correspondence and reprint requests to Dr. F. Zipp, Department of Neurology, Division of Neuroimmunology, University Hospital Charité, Campus Virchow, Forschungshaus, 2.OG, R. 535, Augustenburger Platz 1, 13353 Berlin, Germany.

Interferon (IFN)-ß, the most effective immunomodulatory treatment for MS, inhibits the proliferation of myelin-specific T cells. We report that IFN-ß moderately enhances the expression of the death receptor, CD95, at the surface of human antigen-specific T cells. However, T-cell apoptosis was not induced by IFNß-1a or IFNß-1b as assessed by caspase activity or DNA fragmentation. Immunomodulation mediated by IFN-ß does not directly involve apoptotic pathways in human T cells.

Key words: MS—Interferon-ß—Apoptosis—CD95—Caspase




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