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From the Department of Neurology (Drs. Ruottinen and Rinne), University of Turku; Haaga Neurological Research Centre (Drs. Partinen and Hublin), Helsinki; and Turku PET Centre (J. Bergman, M. Haaparanta, and Drs. Solin and Rinne), Turku, Finland.
Address correspondence and reprint requests to Dr. Hanna M. Ruottinen, Department of Neurology, University of Turku, FIN-20520 Turku, Finland.
The authors investigated nine drug-naïve patients with periodic limb movement disorder and restless legs syndrome (PLMD-RLS) and 27 healthy controls with PET using 6-[18F]fluoro-L-dopa (FDOPA). In the patients, the FDOPA uptake (Kiocc) in the caudate nucleus was 88% and in the putamen 89% of the control mean values. This equal affection of the caudate and the putamen differs, for example, from the dopaminergic dysfunction in Parkinson’s disease, which affects the putamen earlier and more severely than the caudate. The current results indicate mild nigrostriatal presynaptic dopaminergic hypofunction in PLMD-RLS.
Key words: Dopamine—FDOPA PET—Periodic limb movement disorder—Restless legs syndrome
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