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Neurology 2000;54:507
© 2000 American Academy of Neurology


Brief Communications

A magnetization transfer imaging study of the brain in patients with migraine

M. A. Rocca, MD, B. Colombo, MD, A. Pratesi, G. Comi, MD and M. Filippi, MD

From the Neuroimaging Research Unit, Departments of Neuroscience (Drs. Rocca and Filippi, and A. Pratesi) and Neurology (Drs. Colombo and Comi), Scientific Institute Ospedale San Raffaele, University of Milan, Italy.

Address correspondence and reprint requests to Dr. Massimo Filippi, Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy.

The authors evaluated the magnetization transfer ratio (MTR) of T2 lesions, normal-appearing white matter (NAWM), and brain from 39 migraineurs, 17 healthy volunteers, and 22 patients with MS. Migraineurs had NAWM and brain MTR values similar to those of normal subjects but significantly higher than those of MS patients. Average lesion MTR values also were significantly lower in MS patients than in migraineurs. In patients with migraine, other etiologies should be considered in the presence of tissue damage beyond that seen on T2-weighted scans.

Key words: Migraine—MRI—Magnetization transfer imaging




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