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Neurology 2000;54:732
© 2000 American Academy of Neurology
Brief Communications

Anti-inflammatory drugs and Alzheimer-type pathology in aging

Ian R. A. Mackenzie, MD

From the Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada.

Address correspondence and reprint requests to Dr. Ian R.A. Mackenzie, Department of Pathology and Laboratory Medicine, Section of Neuropathology, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, Canada V5Z 1M9; e-mail: imackenz{at}vanhosp.bc.ca

Anti-inflammatory drugs have been suggested as a treatment for AD. The authors examined the AD-type pathology in postmortem brain tissue from elderly nondemented individuals who were chronically exposed to anti-inflammatory drugs. The results suggest that 1) these drugs do not affect the formation of either senile plaques or neurofibrillary tangles and 2) nonsteroidal anti-inflammatory drugs may be more effective than steroids in treating AD because of their ability to suppress the microglial activation associated with senile plaques.

Key words: AD—Senile plaques—Inflammation—Microglia—Anti-inflammatory drugs—Steroids—Nonsteroidal anti-inflammatory drugs




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