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Neurology 2000;54:743
© 2000 American Academy of Neurology
Brief Communications

AIDS- and non–AIDS-related PML association with distinct p53 polymorphism

C. Power, MD, J. G. Brown Gladden, PhD, W. Halliday, MD, M. R. Del Bigio, MD, PhD, A. Nath, MD, W. Ni, MSc, E. O. Major, PhD, J. Blanchard, MD, PhD and M. Mowat, PhD

From the Department of Clinical Neurosciences (Dr. Power and W. Ni), University of Calgary, Alberta; Departments of Pharmacology and Therapeutics (Dr. Power), Pathology (Drs. Halliday and Del Bigio), and Medical Microbiology (Dr. Blanchard), University of Manitoba, and Manitoba Institute for Cell Biology (Drs. Gladden and Mowat), Winnipeg, Canada; Department of Neurology, Microbiology and Immunology (Dr. Nath), University of Kentucky, Lexington; and Laboratory of Molecular Medicine and Neuroscience (Dr. Major), National Institute of Neurological Disorders and Stroke, Bethesda, MD.

Address correspondence and reprint requests to Dr. C. Power, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada T2N 4N1.

A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% among patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients. These findings indicate that frequencies of non–AIDS- and AIDS-related PML differ markedly but p53 polymorphisms may influence the occurrence of PML in both groups.

Key words: Progressive multifocal leukoencephalopathy—AIDS—p53 polymorphism




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