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Neurology 2000;54:757
© 2000 American Academy of Neurology
Brief Communications

Recombinant calcium channel is recognized by Lambert–Eaton myasthenic syndrome antibodies

Kazuo Iwasa, MD, Masaharu Takamori, MD, Kiyonobu Komai, MD and Yasuo Mori, PhD

From the Department of Neurology (Drs. Iwasa and Komai), Kanazawa University School of Medicine, Kanazawa; Neurological Center (Dr. Takamori), Kanazawa-Nishi Hospital, Kanazawa; and the Department of Information Physiology (Dr. Mori), National Institute for Physiological Sciences, Okazaki, Japan.

Address correspondence and reprint requests to Dr. Masaharu Takamori, Neurological Center, Kanazawa-Nishi Hospital, 77, Ko, Kita-machi, Kanazawa, Ishikawa 920-0055 Japan.

The authors studied sera from 36 patients with Lambert–Eaton myasthenic syndrome (LEMS) by immunoblots using the recombinant protein derived from the DNA sequence encoding for the domain III S5-S6 linker of the P/Q-type voltage-gated calcium channel {alpha}1 subunit. The results of 18 patients were positive for antibodies to this recombinant protein. The results of 2 of 10 patients with lung cancer without LEMS were also positive.

Key words: Lambert–Eaton myasthenic syndrome—Neuromuscular transmission—P/Q-type voltage-gated calcium channel—Autoimmunity—Small-cell lung carcinoma




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[Abstract] [Full Text] [PDF]


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