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Cortical reorganization after acute unilateral hearing loss traced by fMRI

From the Departments of Radiology (Drs. Bilecen, Radü, and Wetzel), Psychiatry (Dr. Seifritz), and Otorhinolaryngology (Drs. Schmid and Probst), University of Basel, Switzerland; and the Section of Medical Physics, Department of Diagnostic Radiology (Dr. Scheffler), University of Freiburg, Germany.

Address correspondence and reprint requests to Dr. Erich Seifritz, Department of Psychiatry, University of Basel, Psychiatric University Hospital, Wilhelm Kleinstr. 27, CH-4025 Basel, Switzerland.

Unilateral acoustic stimulation produces a functional MRI (fMRI)–blood-oxygenation-level-dependent (BOLD) response mainly in the contralateral auditory cortex. In unilateral deaf patients, the BOLD response is bilateral. We studied a subject with sudden hearing loss after cochlear nerve resection before and repeatedly after surgery. During normal bilateral hearing, contralateral cortical BOLD responses were found. Progressing compensatory reorganization with bilateral representation of unilateral stimulation was detected over a period of approximately 1 year.

Key words: Neuronal plasticity—fMRI—Acoustic stimulation—Auditory cortex

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