| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Neurology, the Gertrude H. Sergievsky Center (Drs. Manly, Merchant, Jacobs, Small, Bell, and Mayeux) and the Taub Institute on Alzheimer’s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons; and the Department of Obstetrics and Gynecology (Dr. Ferin), Columbia University College of Physicians and Surgeons, New York, NY.
Address correspondence and reprint requests to Dr. Richard Mayeux, Gertrude H. Sergievsky Center, 630 West 168th Street, New York, NY 10032-3702; e-mail: rm20{at}columbia.edu
BACKGROUND: Although several studies have suggested that hormone replacement therapy lowers the risk of AD among postmenopausal women, few studies have evaluated the relationship of endogenous estrogen levels and AD. The current study investigated whether serum estrone and estradiol levels were related to the presence of AD among postmenopausal women not currently taking hormone replacement therapy.
METHODS: Using a case–control design, we examined an ethnically diverse sample of postmenopausal women who met National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association criteria for AD (n = 50) and nondemented controls (n = 93). All women were participants in a study of aging and dementia and were seen consecutively between August 1997 and October 1998.
RESULTS: Patients with AD had lower estradiol (F[1,141] = 8.3, p = 0.005) levels than did normal controls. Patients also had lower estrone levels; however, this comparison did not quite meet significance criteria (F[1,141] = 3.6, p = 0.06). Compared to estradiol levels >20 pg/mL, women with AD were four to six times more likely to have levels <20 pg/mL after adjusting for age, years of education, presence of an APOE-
4 allele, ethnicity, and body mass index. There were no significant differences in frequency of AD among women within different quartiles of estrone after adjusting for potential confounds.
CONCLUSIONS: The results of this preliminary case–control study suggest that estradiol levels may decline significantly in women in whom AD develops.
Key words: Hormone replacement therapy—AD—Estradiol levels—Estrone levels
This article has been cited by other articles:
|
|
 |
|
  K. M. Webber, G. Perry, M. A. Smith, and G. Casadesus The Contribution of Luteinizing Hormone to Alzheimer Disease Pathogenesis Clin. Med. Res., October 1, 2007; 5(3): 177 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Bowen, G. Verdile, T. Liu, A. F. Parlow, G. Perry, M. A. Smith, R. N. Martins, and C. S. Atwood Luteinizing Hormone, a Reproductive Regulator That Modulates the Processing of Amyloid-{beta} Precursor Protein and Amyloid-{beta} Deposition J. Biol. Chem., May 7, 2004; 279(19): 20539 - 20545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hestiantoro and D. F. Swaab Changes in Estrogen Receptor-{alpha} and -{beta} in the Infundibular Nucleus of the Human Hypothalamus Are Related to the Occurrence of Alzheimer's Disease Neuropathology J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1912 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Clark and J. H.T. Karlawish Alzheimer Disease: Current Concepts and Emerging Diagnostic and Therapeutic Strategies Ann Intern Med, March 4, 2003; 138(5): 400 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Senanarong, S. Vannasaeng, N. Poungvarin, S. Ploybutr, S. Udompunthurak, P. Jamjumras, L. Fairbanks, and J. L. Cummings Endogenous Estradiol in Elderly Individuals: Cognitive and Noncognitive Associations Arch Neurol, March 1, 2002; 59(3): 385 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. FRIEDLANDER The physiology, medical management and oral implications of menopause J Am Dent Assoc, January 1, 2002; 133(1): 73 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mayeux Can Estrogen or Selective Estrogen-Receptor Modulators Preserve Cognitive Function in Elderly Women? N. Engl. J. Med., April 19, 2001; 344(16): 1242 - 1244. [Full Text] [PDF]
|
|
|
|
|
|
C. J. Cunningham, M. Sinnott, A. Denihan, M. Rowan, J. B. Walsh, R. O’Moore, D. Coakley, R. F. Coen, B. A. Lawler, and D. D. O’Neill Endogenous Sex Hormone Levels in Postmenopausal Women with Alzheimer's Disease J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1099 - 1103. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
