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From the Sanders–Brown Center on Aging (Drs. Smith, Wang, and Markesbery) and the Departments of Neurology (Drs. Smith and Markesbery), Preventive Medicine (Dr. Snowdon), and Pathology (Dr. Markesbery), University of Kentucky Medical Center, Lexington.
Address correspondence and reprint requests to Dr. Charles D. Smith, Room 113, MRISC Building, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536; e-mail: csmith{at}mri.uky.edu
OBJECTIVE: To determine the relationship between MRI periventricular white matter hyperintensities, cerebral white matter volumes, neuropathologic findings, and cognitive status in aged individuals.
BACKGROUND: The significance of periventricular white matter hyperintensities seen on MR images in aged individuals remains controversial. The Nun Study is a longitudinal cohort aging study in which all 678 initially enrolled participants agreed to autopsy neuropathologic examination.
METHODS: We used MRI to measure white matter volumes of the cerebral hemispheres in 52 formaldehyde-fixed brains for correlation with white matter and neocortical pathology, postmortem MRI observations, and cognitive measures.
RESULTS: Reduced white matter volume is associated with dementia, but periventricular white matter hyperintensities were not related to white matter volume, stroke, or dementia.
CONCLUSIONS: Our results do not support the hypothesis that periventricular hyperintensities seen on MR images have deleterious consequences in these aged individuals.
Key words: White matter volumes—Periventricular white matter hyperintensities—Dementia
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