Neurology
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Neurology 2000;54:987-989
© 2000 American Academy of Neurology
Brief Communications

Cerebral CO2 reactivity, cholesterol, and high-density lipoprotein cholesterol in the elderly

S. L. M. Bakker, MD, F.-E. de Leeuw, MD, PhD, P. J. Koudstaal, MD, PhD, A. Hofman, MD, PhD and M. M. B. Breteler, MD, PhD

From the Department of Neurology (Drs. Bakker, and Koudstaal), University Hospital Rotterdam; the Department of Epidemiology & Biostatistics (Drs. Bakker, de Leeuw, Hofman, and Breteler), Erasmus University Medical School, Rotterdam; and the Department of Neurology (Dr. de Leeuw), University Medical Center Utrecht, the Netherlands.

Address correspondence and reprint requests to Dr. S.L.M. Bakker, Department of Neurology, University Hospital Rotterdam, Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands; e-mail: bakker{at}neur.azr.nl

Cholesterol and its subfractions play a role in the development of atherosclerosis. Cerebral CO2 reactivity reflects the compensatory capacity of cerebral arterioles. The authors investigated the relationship between total cholesterol, high-density lipoprotein (HDL), their ratio, and cerebral CO2 reactivity in 826 participants from the Rotterdam Study. Cerebral CO2 reactivity increased significantly with increasing levels of HDL and decreased significantly with an increasing total cholesterol/HDL ratio. This suggests that blood lipids may also affect smaller cerebral blood vessels.

Key words: Ultrasonography—Doppler—Transcranial—Cerebral CO2 reactivity—Cholesterol (ratio)—High-density lipoprotein cholesterol—Population






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