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Language disturbances in corticobasal degeneration

From the Speech-Language Pathology Section, Rehabilitation Medicine Department (Dr. Frattali), and Department of Radiology (Dr. Patronas), National Institutes of Health Clinical Center, Bethesda, MD; the Cognitive Neuroscience Section (Dr. Grafman), National Institute of Neurological Disorders and Stroke, Bethesda, MD; the Center for Information and Technology (F. Makhlouf), National Institutes of Health; and the Cognitive Neuropharmacology Unit (Dr. Litvan), Henry M. Jackson Foundation, Bethesda, MD.

Address correspondence and reprint requests to Dr. Irene Litvan, Cognitive Neuropharmacology Unit, Henry M. Jackson Foundation, The Champlain Building, 6410 Rockledge Drive, Suite 600, Bethesda, MD 20817-1844; e-mail: ilitvan{at}dvhip.org

To characterize the language deficits in corticobasal degeneration (CBD) and their relation to neuroradiologic findings, the authors administered a standardized battery of neurobehavioral tests and performed MRI studies on 15 patients with CBD. Eight patients (53%) had classifiable aphasias, including anomic, Broca’s and transcortical motor aphasias. The aphasias were associated primarily with left frontal and parietal cortical damage and subcortical white matter and corpus callosum abnormalities. Our findings demonstrate that language disturbances in CBD are more frequent than previously considered.

Key words: Corticobasal degeneration—Aphasia—Language disturbances

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