Neurology
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Neurology 2000;54:997-1000
© 2000 American Academy of Neurology


Brief Communications

Longitudinal study of neurotoxicity with occupational exposure to aluminum dust

S. Letzel, MD, MSc, C. J. G. Lang, MD, K. H. Schaller, MSc, J. Angerer, PhD, S. Fuchs, MD, B. Neundörfer, MD and G. Lehnert, MD

From the Institute and Outpatient Department for Occupational, Social and Environmental Medicine (Drs. Letzel, Angerer, and Lehnert, and K. H. Schaller), University of Erlangen-Nuremberg, Erlangen; and the Neurological Hospital (Drs. Lang, Fuchs, and Neundörfer), University of Erlangen-Nuremberg, Erlangen, Germany.

Address correspondence and reprint requests to Dr. Stephan Letzel, Institut für Arbeits-, Sozial- und Umweltmedizin, Schillerstr. 25/29, D-91054 Erlangen, Germany; e-mail: stephan.letzel{at}rzmail.uni-erlangen.de

Two cross-sectional studies were conducted at a German aluminum (Al) powder plant to evaluate possible nervous system effects from occupational Al exposure. The investigation included biological monitoring, a neuropsychological test battery, and event-related P300 potentials. Neurophysiologic findings in workers chronically exposed to Al dust did not differ from non–Al-exposed controls from the same plant. The authors suggest that chronic exposure to Al dust, at the levels documented in this study, does not induce measurable cognitive decline.

Key words: Aluminum—Toxicology—Occupational exposure—Neuropsychological testing—Cognitive decline







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