| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Division of Geriatrics and Neuropsychiatry, Department of Psychiatry, and Alzheimer’s Disease Research Center (Drs. Ganguli and DeKosky), University of Pittsburgh School of Medicine; and the Department of Epidemiology (Drs. Ganguli, Dodge, Chen, and Belle), University of Pittsburgh Graduate School of Public Health, PA.
Address correspondence and reprint requests to Dr. Mary Ganguli, Western Psychiatric Institute and Clinic, 3811 O’Hara Street, Pittsburgh, PA 15213-2593.
OBJECTIVE: To determine incidence rates by age, sex, and education of overall dementia and probable/possible AD in a largely rural community.
METHODS: Ten-year prospective study of a randomly selected community sample aged 65+; biennial cognitive screening followed by standardized clinical evaluation. Incidence rates were estimated for overall dementia (Diagnostic and Statistical Manual of Mental Disorders, 3rd ed., revised, criteria and Clinical Dementia Rating [CDR]) and for probable/possible AD (National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association criteria).
RESULTS: The cohort consisted of 1,298 individuals free of dementia at study entry. Among these, 199 incident (new) cases of overall (all-cause) dementia with CDR stage 
0.5, including 110 with CDR 1, were detected during follow-up. Among the incident cases, 153 (76.9%) had probable/possible AD. Age-specific incidence rates are reported for all dementia and for probable/possible AD, by sex and CDR stage. Among all-cause dementias with CDR = 0.5, controlling for age and education, men had a higher incidence rate than women. In the same group, those with less than high school education had significantly higher incidence rates than those with more education. Rates did not vary significantly by sex or education for probable/possible AD or for dementia with CDR 1.
CONCLUSIONS: Incidence rates of all dementias and of AD increased with age; men and those with lesser education had higher rates of possible/incipient dementia (CDR = 0.5) in this community. Potential explanations for these sex and education effects are discussed.
Key words: Aging—AD—Epidemiology—Population-based cohort study.
This article has been cited by other articles:
|
|
 |
|
  M. Lorena Chaves, A. Luiza Camozzato, C. Godinho, I. Piazenski, and J. Kaye Incidence of Mild Cognitive Impairment and Alzheimer Disease in Southern Brazil J Geriatr Psychiatry Neurol, September 1, 2009; 22(3): 181 - 187. [Abstract] [PDF]
|
|
|
|
 |
|
 J.C.S. Breitner, S. J.P.A. Haneuse, R. Walker, S. Dublin, P. K. Crane, S. L. Gray, and E. B. Larson Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort Neurology, June 2, 2009; 72(22): 1899 - 1905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Matsui, Y Tanizaki, H Arima, K Yonemoto, Y Doi, T Ninomiya, K Sasaki, M Iida, T Iwaki, S Kanba, et al. Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama study J. Neurol. Neurosurg. Psychiatry, April 1, 2009; 80(4): 366 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Jalbert, L. A. Daiello, and K. L. Lapane Dementia of the Alzheimer Type Epidemiol. Rev., November 1, 2008; 30(1): 15 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Szekely, R. C. Green, J.C.S. Breitner, T. Ostbye, A. S. Beiser, M. M. Corrada, H. H. Dodge, M. Ganguli, C. H. Kawas, L. H. Kuller, et al. No advantage of A{beta}42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies Neurology, June 10, 2008; 70(24): 2291 - 2298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Buter, A. van den Hout, F. E. Matthews, J. P. Larsen, C. Brayne, and D. Aarsland Dementia and survival in Parkinson disease: A 12-year population study Neurology, March 25, 2008; 70(13): 1017 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ngandu, E. von Strauss, E. -L. Helkala, B. Winblad, A. Nissinen, J. Tuomilehto, H. Soininen, and M. Kivipelto Education and dementia: What lies behind the association? Neurology, October 2, 2007; 69(14): 1442 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. Dodge, Y. Du, J. A. Saxton, and M. Ganguli Cognitive Domains and Trajectories of Functional Independence in Nondemented Elderly Persons J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2006; 61(12): 1330 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ganguli, Y. Du, H. H. Dodge, G. G. Ratcliff, and C.-C. H. Chang Depressive Symptoms and Cognitive Decline in Late Life: A Prospective Epidemiological Study Arch Gen Psychiatry, February 1, 2006; 63(2): 153 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ganguli, J. V. Bilt, J. A. Saxton, C. Shen, and H. H. Dodge Alcohol consumption and cognitive function in late life: A longitudinal community study Neurology, October 25, 2005; 65(8): 1210 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Barnes, R. S. Wilson, J. L. Bienias, J. A. Schneider, D. A. Evans, and D. A. Bennett Sex Differences in the Clinical Manifestations of Alzheimer Disease Pathology Arch Gen Psychiatry, June 1, 2005; 62(6): 685 - 691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Ravaglia, P. Forti, F. Maioli, M. Martelli, L. Servadei, N. Brunetti, E. Dalmonte, M. Bianchin, and E. Mariani Incidence and etiology of dementia in a large elderly Italian population Neurology, May 10, 2005; 64(9): 1525 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ganguli, H. H. Dodge, C. Shen, R. S. Pandav, and S. T. DeKosky Alzheimer Disease and Mortality: A 15-Year Epidemiological Study Arch Neurol, May 1, 2005; 62(5): 779 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Tornatore, E. Hill, J. A. Laboff, and M. E. McGann Self-Administered Screening for Mild Cognitive Impairment: Initial Validation of a Computerized Test Battery J Neuropsychiatry Clin Neurosci, February 1, 2005; 17(1): 98 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-P. Jin, M. Gatz, B. Johansson, and N. L. Pedersen Sensitivity and specificity of dementia coding in two Swedish disease registries Neurology, August 24, 2004; 63(4): 739 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ganguli, H. H. Dodge, C. Shen, and S. T. DeKosky Mild cognitive impairment, amnestic type: An epidemiologic study Neurology, July 13, 2004; 63(1): 115 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Pandav, H. H. Dodge, S. T. DeKosky, and M. Ganguli Blood Pressure and Cognitive Impairment in India and the United States: A Cross-National Epidemiological Study Arch Neurol, August 1, 2003; 60(8): 1123 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Dodge, C. Shen, R. Pandav, S. T. DeKosky, and M. Ganguli Functional Transitions and Active Life Expectancy Associated With Alzheimer Disease Arch Neurol, February 1, 2003; 60(2): 253 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Mulsant, B. G. Pollock, M. Kirshner, C. Shen, H. Dodge, and M. Ganguli Serum Anticholinergic Activity in a Community-Based Sample of Older Adults: Relationship With Cognitive Performance Arch Gen Psychiatry, February 1, 2003; 60(2): 198 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Kukull, R. Higdon, J. D. Bowen, W. C. McCormick, L. Teri, G. D. Schellenberg, G. van Belle, L. Jolley, and E. B. Larson Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study Arch Neurol, November 1, 2002; 59(11): 1737 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ganguli, H. H. Dodge, and B. H. Mulsant Rates and Predictors of Mortality in an Aging, Rural, Community-Based Cohort: The Role of Depression Arch Gen Psychiatry, November 1, 2002; 59(11): 1046 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Knopman, W. A. Rocca, R. H. Cha, S. D. Edland, and E. Kokmen Incidence of Vascular Dementia in Rochester, Minn, 1985-1989 Arch Neurol, October 1, 2002; 59(10): 1605 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Qiu, L. Backman, B. Winblad, H. Aguero-Torres, and L. Fratiglioni The Influence of Education on Clinically Diagnosed Dementia Incidence and Mortality Data From the Kungsholmen Project Arch Neurol, December 1, 2001; 58(12): 2034 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chandra, R. Pandav, H.H. Dodge, J.M. Johnston, S.H. Belle, S.T. DeKosky, and M. Ganguli Incidence of Alzheimer's disease in a rural community in India: The Indo-US Study Neurology, September 25, 2001; 57(6): 985 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Chen, G. Ratcliff, S. H. Belle, J. A. Cauley, S. T. DeKosky, and M. Ganguli Patterns of Cognitive Decline in Presymptomatic Alzheimer Disease: A Prospective Community Study Arch Gen Psychiatry, September 1, 2001; 58(9): 853 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Chen, G. Ratcliff, S. H. Belle, J. A. Cauley, S. T. DeKosky, and M. Ganguli Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented Neurology, December 26, 2000; 55(12): 1847 - 1853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ganguli, V. Chandra, M. I. Kamboh, J. M. Johnston, H. H. Dodge, B. K. Thelma, R. C. Juyal, R. Pandav, S. H. Belle, and S. T. DeKosky Apolipoprotein E Polymorphism and Alzheimer Disease: The Indo-US Cross-National Dementia Study Arch Neurol, June 1, 2000; 57(6): 824 - 830. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
