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From the Department of Neurology (Drs. Tan, Matsuura, Nagamitsu, Jankovic, and Ashizawa, and M. Khajavi), Baylor College of Medicine; and the Neurology Service (Drs. Matsuura, Nagamitsu, and Ashizawa, and M. Khajavi), VA Medical Center, Houston, TX.
Address correspondence and reprint requests to Dr. Tetsuo Ashizawa, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Smith 1801, Houston, TX 77030; e-mail: tetsuoa{at}bcm.tmc.edu
An allele (263bp) of the nonamyloid component of plaques (NACP)-Rep1 polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington’s disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.
Key words: PD—Essential tremor—NACP—Rep1—Polymorphism.
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